WIN-34B showed analgesic and anti-inflammatory effects in various animal models of pain and osteoarthritis. However, the molecular mechanism by which WIN-34B inhibits pain and inflammation in vivo remains to be elucidated. We investigated the molecular mechanisms of the actions of WIN-34B using various in vitro models using fibroblast-like synoviocytes from patients with rheumatoid arthritis (R...

BACKGROUND Cannabinoid, particularly hashish and WIN 55212-2 (WIN), consumption during embryonic period may affect fetal growth, and the development of motor functioning, memory and cognitive functions. Therefore, the present study aimed to evaluate the effects of WIN 55212-2 during embryonic period on behavioral responses, as well as tissue and memory changes among neonatal rats. METHODS WIN...

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Abstract Phototherapy usually includes photodynamic therapy (PDT) and photothermal (PTT) to induce cell death. PDT utilizes the sensitization of photosensitizers generate reactive oxygen species by intersystem crossing while PTT undergoes nonradiative decay heat. Cancer immunotherapy has evolved as a new therapeutic modality eradicate tumor cells activating antigen-presenting cells, thus, induc...

Large archives of astronomical data (images, spectra and catalogues of derived parameters) are being assembled worldwide as part of the Virtual Observatory project. In order for such massive heterogeneous data collections to be of use to astronomers, development of Computational Intelligence techniques that would combine modern machine learning with deep domain knowledge is crucial. Both fields...

Women wishing to combine children with a research career should not be seen as taking a backstep but as bolstering both activities, argues Marlene Belfort.