A 42-year-old woman was referred for radiofrequency catheter ablation of narrow QRS tachycardia that was terminated with intravenous adenosine. Baseline twelve-lead ECG was normal during sinus rhythm and transthoracic echocardiography demonstrated no evidence of structural heart disease. The electrophysiological study showed a normal AH interval of 114 ms and HV interval of 37 ms during sinus r...

An electrocardiographic atlas of ventricular tachycardias was produced by pacing 27 epicardial sections of the heart and the mitral papillary muscles to simulate focal ventricular arrhythmias and simultaneously recording their 12 lead electrocardiographic appearances. One hundred and twenty nine patients undergoing cardiac surgery were studied. In five patients all 27 epicardial sites were pace...

AIMS The prognostic implications of QRS duration and morphology in heart failure patients treated with cardiac resynchronization therapy (CRT) remains debated. The present evaluation investigated the association between QRS duration (<150 vs. ≥150 ms) and QRS morphology (left bundle brand block [LBBB] vs. non-LBBB) and long-term prognosis of a large cohort of unselected heart failure patients t...

BACKGROUND Has been reported that patients exhibiting prolonged paced QRS duration tend to have more serious heart disease, and the paced QRS duration can be an effective indicator of impaired left ventricular function. However, the acute and chronic hemodynamic effects of paced QRS duration and pacing sites during right ventricular (RV) pacing remain unknown. METHODS A total of 14 patients w...

OBJECTIVE Loperamide, a non-prescription anti-diarrheal agent, is a peripheral mu-opioid receptor agonist that is excluded from the blood-brain barrier by p-glycoprotein at therapeutic doses. Overdoses of loperamide penetrate the central nervous system (CNS), leading to abuse. We report cardiac conduction abnormalities and dysrhythmias after ingestion of a recreational supra-therapeutic dose of...

OBJECTIVE Despite progresses in surgical correction of Tetralogy of Fallot, pulmonary insufficiency and progressive dysfunction of the right ventricle impress its long-term prognosis. In this study we examined the correlations between QRS duration, pulmonary insufficiency and right ventricular performance index. METHODS We enrolled 57 repaired Tetralogy of Fallot patients. QRS duration on ele...

We present a parameterized widening operator that determines the control-flow sensitivity of an analysis, i.e., its flow-sensitivity, context-sensitivity, and path-sensitivity. By instantiating the operator’s parameter in different ways, the analysis can be tuned to arbitrary sensitivities without changing the abstract semantics of the analysis itself. Similarly, the analysis can be implemented...

Convex polyhedra constitute the most used abstract domain among those capturing numerical relational information. Since the domain of convex polyhedra admits infinite ascending chains, it has to be used in conjunction with appropriate mechanisms for enforcing and accelerating convergence of the fixpoint computation. Widening operators provide a simple and general characterization for such mecha...

IMPORTANCE The benefits of cardiac resynchronization therapy (CRT) in clinical trials were greater among patients with left bundle-branch block (LBBB) or longer QRS duration. OBJECTIVE To measure associations between QRS duration and morphology and outcomes among patients receiving a CRT defibrillator (CRT-D) in clinical practice. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study...

BACKGROUND AND OBJECTIVES Neural blockade techniques are associated with a risk of acute cardiac toxicity after accidental intravenous (IV) injection of local anesthetics. The aim of this study was to compare electrocardiographic (ECG) and hemodynamic (HEM) effects induced by IV infusion of local anesthetics in an anesthetized ewe model. METHODS Thirty-two anesthetized ewes received IV bupiva...