BACKGROUND The use of niacin in the treatment of dyslipidemias is limited by the common side effect of cutaneous vasodilation, commonly termed flushing. Flushing is thought to be due to release of the vasodilatory prostanoids prostaglandin D2 (PGD2) and prostaglandin E2 from arachidonic acid metabolism through the cyclooxygenase pathway. Arachidonic acid is also metabolized by the cytochrome P4...

BACKGROUND Niacin is widely available over the counter (OTC). We sought to determine the safety of 500 mg immediate release niacin, when healthy individuals use them as directed. METHODS 51 female and 17 male healthy volunteers (mean age 27 years SD 4.4) participated in a randomized placebo-controlled blinded trial of a single dose of an OTC, immediate-release niacin 500 mg (n = 33), or a sin...

BACKGROUND Coal tar and bitumen have been historically used to coat the insides of cast iron drinking water mains. Polycyclic aromatic hydrocarbons (PAHs) may leach from these coatings into the drinking water and form a potential health risk for humans. OBJECTIVE We estimated the potential human cancer risk from PAHs in coated cast iron water mains. METHOD In a Dutch nationwide study, we co...

L’étude a porté sur les effets des caractéristiques du troupeau (race, taille, parité et zone d’étude) pratiques d’élevage (chaleurs induites/naturelles, pratique flushing ou non, durée tarissement) taux de fécondité fertilité 721 vaches laitières (VL) races Montbéliarde (n = 379) Prim’Holstein 342) réparties 23 troupeaux, nées mises à la reproduction en Algérie. Les paramètres ont révélé un in...

Hypercholesterolemia is one of the main factors in the development of atherosclerotic cardiovascular disease. The advent of statins led to huge progress in the treatment of hypercholesterolemia, yet the proportion of patients with prohibitive lipid values and the high incidence of cardiovascular events despite treatment are still very high. Niacin, one of the older drugs used to treat hyperlipi...

The experimental approach has been used to study successfully the relationship between the polymorphism of aldehyde dehydrogenase 2 and the flushing syndrome. In the present study, a probabilistic approach was used to analyse this relationship. Using cross-impact analysis and experimental data, the probability of the occurrence of flushing, the extent by which ALDH2*2/*2 enhances flushing more ...

Background: Due to the seasonality reproduction of albino hamster (April to October in the Northern Hemisphere) and the need to produce blastocysts for research applications, producing and collecting blastocysts by natural mating in non-breeding season is complex in this species. In the present study in vivo blastocysts production and collection using super-ovulation and intrauterine inseminati...

BACKGROUND Flushing is generally considered to be the primary symptom of menopause and is typically the most common complaint in menopausal women. Although flushing poses no danger to a woman's health, it decreases the quality of life. Thus, the purpose of this study was to determine the effect of lavender aromatherapy on menopause flushing. METHODS This double-blinded crossover clinical tria...