The hippocampal system plays an important role in memory function. Neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. Many biological effects of estrogens in the brain via estrogenic receptors (ERs) are investigated. The current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The curre...

The open question, which seems to be also the final part, in terms of studying Cauchy problem for weakly coupled system damped wave equations or reaction-diffusion equations, is so far known as sharp lifespan estimates critical case. In this paper, we mainly investigate solutions semilinear By using a suitable test function method associated with nonlinear differential inequalities, catch upper...

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (MYOC) dominant gain-of-function mutations have been reported in ∼4% of POAG cases. MYOC mutations result in protein misfolding, leading to endoplasmic reticulum (ER) stress in the trabecular meshwork (TM), the tissue that regulates ...

We continue the work of Camano et al . [ SIAM J. Math. Anal. 49 (2017) 4376–4401] on electromagnetic Steklov eigenvalues. The authors recognized that in general eigenvalues do not correspond to spectrum a compact operator and hence proposed modified eigenvalue problem with desired properties. present article considers original problem. cast problems as for holomorphic function A (?). construct ...

n this paper, we prove some common fixed point theorems for multivalued mappings and we present some new generalization contractive conditions under the condition of weak compatibility. our results extends chang-chen’s results  as well as ´ciri´c results. an example is given to support the usability of our results.

A switch from estrogen-dependent to estrogen-independent growth is a critical step in malignant progression of breast cancer and is a major problem in endocrine therapy. However, the molecular mechanisms underlying this switch remain poorly understood. The Wilms' tumor suppressor gene, wt1, encodes a zinc finger protein WT1 that functions as a transcription regulator. High levels of the WT1 exp...

In 2001, S. Bulman-Fleming et al. initiated the study of three flatness properties (weakly kernel flat, principally weakly kernel flat, translation kernel flat) of right acts $A_{S}$ over a monoid $S$ that can be described by means of when the functor $A_{S} otimes -$ preserves pullbacks. In this paper, we extend these results to $S$-posets and present equivalent descriptions of weakly kernel p...

Let $R$ be a commutative ring. The purpose of this article is to introduce a new class of ideals of R called weakly irreducible ideals. This class could be a generalization of the families quasi-primary ideals and strongly irreducible ideals. The relationships between the notions primary, quasi-primary, weakly irreducible, strongly irreducible and irreducible ideals, in different rings, has bee...