Brain metastases (BM) are found in approximately 20-40% of all patients with non-small-cell lung cancer (NSCLC), especially in adenocarcinoma (Olak 1999; Yawn et al., 2003). The outcomes of BM from NSCLC are very poor with few effective treatment options. The median overall survival time (OS) of patients without treatment is less than 3 months (Nussbaum et al., 1996). Whole brain radiotherapy (...

Despite recent advances in technology, targeting, and chemotherapy, brain metastasis from non-small cell lung cancer (NSCLC) remains a significant problem. The vast majority of patients with this diagnosis undergo whole brain radiation therapy (WBRT). However, outcomes are still quite poor with median survivals measured in only months. In an effort to enhance outcomes from external beam radiati...

Brain tumors constitute the most common intracranial tumor. Management of brain metastases has become increasingly complex as patients with brain metastases are living longer and more treatment options develop. The goal of this paper is to review the role of stereotactic radiosurgery (SRS), whole brain radiation therapy (WBRT), and surgery, in isolation and in combination, in the contemporary t...

Una única dosis de radioterapia intraoperatoria (IORT) en cáncer mama precoz (EBC) puede ser una opción frente a la externa estándar (WBRT). Sin embargo, no existe consenso sobre su uso y resultados. Analizar morbilidad resultados oncológicos IORT como monoterapia el tratamiento del EBC. Se realiza un estudio analítico observacional unicéntrico, comparando cohorte prospectiva (2015-17) con retr...

Ahmad I, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-223449 Description A 43-year-old male with a history of receiving treatment for squamous cell carcinoma (SqCC) of lung 2 years back presented with a complaint of a single episode of self-resolving generalised tonic–clonic seizure 1 day prior. General physical and neurological examinations were unremarkable. An MRI of the brain revealed a w...

The purpose of this study was to retrospectively investigate the accuracy, plan quality, and efficiency of using intensity-modulated arc therapy (IMAT) for whole brain radiotherapy (WBRT) patients with sparing not only the hippocampus (following RTOG 0933 compliance criteria) but also other organs at risk (OARs). A total of 10 patients previously treated with nonconformal opposed laterals whole...

Primary CNS lymphoma (PCNSL) is an uncommon type of extranodal non-Hodgkin lymphoma confined to the brain, leptomeninges, or eyes. Although more than 90% of PCNSL tumors are classified histologically as diffuse large B-cell lymphoma, the survival of patients with PCNSL remains inferior to that observed in patients with diffuse large B-cell lymphoma occurring in other body sites. This may result...

Abstract PURPOSE To investigate the effect of radiotherapy and surgery in patients with lung cancer brain metastases (BMs) poor prognosis factors. METHODS We analyzed retrospectively 714 BMs. A 1:1 propensity score matching (PSM) was performed to balance potential confounders. Analyses overall survival (OS) risk factors for OS were assessed by log-rank test Cox proportional hazard model. RESULT...

PURPOSE To determine if the timing of whole brain radiotherapy (WBRT) with respect to chemotherapy with cisplatin and vinorelbine would influence survival in patients with non-small-cell lung cancer (NSCLC) and concurrent brain metastasis. PATIENTS AND METHODS One hundred seventy-six patients with brain metastasis from NSCLC were included in the study between July 1995 and October 1997. All p...

Brain metastases are the most common intracranial tumors in the adult population and have been historically treated with whole brain radiation therapy (WBRT). However, as medical advances improve life expectancy, stereotactic radiosurgery (SRS) has replaced WBRT as the standard of care for limited (one to three) brain metastases due to the relative sparing of neurocognitive function (NCF) and t...