نتایج جستجو برای: water maze

تعداد نتایج: 557571  

Journal: :Frontiers in Integrative Neuroscience 2009
Hamid R. Maei Kirill Zaslavsky Cátia M. Teixeira Paul W. Frankland

The water maze is commonly used to assay spatial cognition, or, more generally, learning and memory in experimental rodent models. In the water maze, mice or rats are trained to navigate to a platform located below the water's surface. Spatial learning is then typically assessed in a probe test, where the platform is removed from the pool and the mouse or rat is allowed to search for it. Perfor...

Journal: :Prague medical report 2007
J Cendelín I Korelusová F Vozeh

Lurcher mutant mice represent a model of olivocerebellar degeneration. They suffer from cerebellar ataxia and deterioration of cognitive functions. The aim of the work was to study the effect of repetitive enforced motor training on spatial learning ability and motor coordination in adult Lurcher mutant mice of the C57BI strain. Experimental mice were trained repetitively on a rotarod. Control ...

2013
GuoXia Zhou WanXia Xiong XiaoGuang Zhang ShengJin Ge

OBJECTIVE To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a water maze. METHODS Twenty-four aged mice were allocated into no training or probe test (naïve), no training but exposed to the same probe test (...

Journal: :Neurobiology of learning and memory 2005
Ana Paula Santana de Vasconcellos Alessandra Ioppi Zugno Ana Helena D P Dos Santos Fabiane Batistela Nietto Leonardo Machado Crema Marialva Gonçalves Renata Franzon Angela Terezinha de Souza Wyse Elizabete Rocha da Rocha Carla Dalmaz

This study was undertaken to verify the effects of chronic stress and lithium treatments on the hippocampal Na+,K(+)-ATPase activity of rats, as well as to investigate the effects of stress interruption and post-stress lithium treatment on this enzyme activity and on spatial memory. Two experiments were carried out; in the first experiment, adult male Wistar rats were divided into two groups: c...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Scellig S D Stone Cátia M Teixeira Loren M Devito Kirill Zaslavsky Sheena A Josselyn Andres M Lozano Paul W Frankland

Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical e...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
V Ramírez-Amaya I Balderas J Sandoval M L Escobar F Bermúdez-Rattoni

Structural synaptic changes have been suggested to underlie long-term memory formation. In this work, we investigate if hippocampal mossy fiber synaptogenesis induced by water maze overtraining can be related with long-term spatial memory performance. Rats were trained in a Morris water maze for one to five identical daily sessions and tested for memory retrieval 1 week and 1 month after traini...

2005
Joanna L. Jankowsky Tatiana Melnikova Daniel J. Fadale Guilian M. Xu Hilda H. Slunt Victoria Gonzales Linda H. Younkin Steven G. Younkin David R. Borchelt Alena V. Savonenko

Epidemiological studies suggest that individuals with greater education or more cognitively demanding occupations have diminished risk of developing dementia. We wanted to test whether this effect could be recapitulated in rodents using environmental enrichment, a paradigm well documented to attenuate behavioral deficits induced by various pathological insults. Here, we demonstrate that learnin...

Journal: :Pharmacology, biochemistry, and behavior 2011
Oguz Mutlu Güner Ulak Ipek Komsuoglu Celikyurt Füruzan Yildiz Akar Faruk Erden

Cognitive dysfunction in schizophrenia is associated with functional disease symptoms. The beneficial effects of second generation antipsychotic drugs on cognitive function in schizophrenic patients are controversial. In this study, we investigated the effects of the second generation antipsychotics olanzapine, sertindole and clozapine on cognitive function in the Morris water maze task in naiv...

Journal: :Physiology & behavior 2004
Alexandre Bélanger Nathalie Lavoie François Trudeau Guy Massicotte Sylvain Gagnon

Previous investigations have demonstrated that cognitive deficits as well as hippocampal dysfunctions are generated in animals presenting manifestations of Type 1 diabetes (T1D) mellitus. The present study examined whether such deficits can also be reproduced in the Zucker Diabetic Fatty (ZDF) rats after they developed symptoms of Type 2 diabetes (T2D). Learning and memory assessments were perf...

Journal: :Stroke 2007
Fanny Wurm Silke Keiner Albrecht Kunze Otto W Witte Christoph Redecker

BACKGROUND AND PURPOSE Environmental stimulation consistently increases dentate neurogenesis in the adult brain and improves spatial learning. We tested the hypothesis whether specific rehabilitative training of an impaired forelimb influences these processes after focal cortical infarcts. METHODS Focal cortical infarcts were induced in the forelimb sensorimotor cortex using the photothrombos...

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