Prader-Willi syndrome described in 1956 has a genetic origin, affecting both genders, varying in presence and intensity from individual to individual. A precocious diagnosis, before the manifestation of symptoms, has brought some improvement in the quality of life of the carriers in the last years. The objective of this case report was to describe the treatment realized in a 3-year-old boy who ...

BACKGROUND Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture, a traditional herb-based formulation, has been successfully used for the management of idiopathic true precocious puberty (IPP) for more than thirty years. Precocious puberty rat model by neonatal administration of Danazol was used to investigate the effects of the herb mixture on the advanced sexual development of the rats, and ...

Familial male-limited precocious puberty (MPP) is described in a 10 year old patient with typical symptoms of the disease. Sequence analysis of genomic DNA clearly demonstrated a heterozygous T1 193C transition in exon 11 of the LH receptor (LHR) gene, which results in M398T substitution in the second transmembrane helix of the protein product of this gene. The same mutation was found in the pa...

A 7-yr-old girl presented with isosexual precocious puberty secondary to a feminizing adrenal adenoma. The adrenal tumor was found to express aromatase messenger ribonucleic acid. Enzyme kinetic studies revealed a high level of aromatase activity in the adrenal tumor, with a K(m) of 45 nmol/L and a maximum velocity of 25.6 pmol/mg.h. Aromatase activity was approximately 500-fold higher in the t...

The aim of this study was to evaluate the ovarian volume and the number of follicles before and after GnRH analogues therapy in girls with previous diagnosis of precocious puberty or thelarche. We collected data from all the girls afferent to the Clinic of Obstetrics and Gynecology and the Clinic of Pediatrics in the University Hospital of Udine (Italy) between 2005 and 2009. 85 girls with a di...

In this session students will evaluate data on precocious puberty and try to find its underlying causes. Read this to the class or discuss it in your own words with them. Be sure that you cover these points: what causes normal puberty; the technical terminology of puberty; is a statistically significant difference in average age at puberty of 3, or 6 months biologically significant? Emphasize t...

Chicks initiate bilateral alternating steps several days before hatching and adaptively walk within hours of hatching, but emergence of precocious walking skills is not well understood. One of our aims was to determine whether interactions between environment and movement experience prior to hatching are instrumental in establishing precocious motor skills. However, physiological evidence of pr...

OBJECTIVE To determine the frequency of 21-hydroxylase deficiency in The Bahamas and the spectrum of this disorder METHODS Patients referred for evaluation of virilization, precocious puberty, ambiguous genitalia and salt wasting had blood taken for 17-hydroxyprogesterone (17-OH progesterone) which was measured by Enzyme-Linked Immunosorbent Assay (ELISA). RESULTS Nine patients had elevated...