The von Hippel-Lindau (VHL) tumour suppressor protein is important in the E3 ubiquitin ligase ECV (Elongin B/C-CUL2-VHL)-mediated destruction of hypoxia-inducible factor and the promotion of fibronectin (FN) extracellular matrix assembly. Although the precise molecular mechanism controlling the selectivity of VHL function remains unknown, a failure in either process is associated with oncogenic...

a Julius-von-Sachs-Institut für Biowissenschaften, Lehrstuhl für Pharmazeutische Biologie, Universität Würzburg, Mittlerer Dallenbergweg 64, D -97082 Würzburg, Fax: 0049 931 8 8 8 6182, Bundesrepublik Deutschland b Gesellschaft für Biotechnologische Forschung mbH, M ascheroder Weg 1, D-38124 Braunschweig.Bundesrepublik Deutschland c Institut für Pharmazeutische Biologie, Technische Universität ...

Von Hippel-Landau (VHL) protein is a potent tumor suppressor regulating numerous pathways that drive cancer, but mutations in VHL are restricted to limited subsets of malignancies. Here we identified a novel mechanism for VHL suppression in tumors that do not have inactivating mutations. Using developmental processes to uncover new pathways contributing to tumorigenesis, we found that Daam2 pro...

Five years after the identification of the von Hippel-Lindau (VHL) gene, physicians, scientists and concerned VHL family members met to review the current state of knowledge on the diagnosis and treatment of VHL and to summarize the latest information on the biochemistry of the VHL protein (pVHL). The NIH and University of Pennsylvania groups reported the detection of germ-line mutations in 100...

C Cybulski, K Krzystolik, A Murgia, B Górski, T Dębniak, A Jakubowska, M Martella, G Kurzawski, M Prost, I Kojder, J Limon, P Nowacki, L Sagan, B Białas, J Kałuża, M Zdunek, A Omulecka, D Jaskólski, E Kostyk, B Koraszewska-Matuszewska, O Haus, H Janiszewska, K Pecold, M Starzycka, R Słomski, M Cuwirko, A Sikorski , B Gliniewicz, L Cyryłowski, Ł Fiszer-Maliszewska, J Gronwald, A Tołoczko-Grabare...

We are going through great changes in information valuation and technology use. The so-called Age of Information or Knowledge Society is characterized by the virtualization of human beings: by the vectors of flexibility, deterritorialization and speed of the information process. The Internet is responsible for transmitting virtual information of mixed – commercial and academic – usage and is ex...

quired abnormalities of megakaryocyte production that could be due to progenitor trapping in the osteoblastic niche? There are elegant techniques available for in vivo microscopy of the marrow space in living animals that could be used to study these questions4 and I am confident that these experiments will be or are being done. I look forward to more details regarding the movement of megakaryo...

It is a report of disseminated bacillary angiomatosis (BA) in a 23-year-old female patient, who is HIV-positive and with fever, weight loss, hepatomegaly, ascites, and papular-nodular skin lesions. The clinical and diagnostic aspects involved in the case were discussed. Bacillary angiomatosis must always be considered in the diagnosis of febrile cutaneous manifestations in AIDS.

Best known for his contributions to the field of embryology [6], Karl Ernst von Baer [5] also pursued a variety of other areas of study including medicine, botany, zoology, and anthropology. Committing his life to scientific research, von Baer?s work led to the advancement of the understanding of mammalian reproduction, development, and organ functioning. His embryological discoveries ultimatel...