INTRODUCTION Assessment of respiratory system compliance (Crs) can be used for individual optimization of positive end-expiratory pressure (PEEP). However, in patients with spontaneous breathing activity, the conventional methods for Crs measurement are inaccurate because of the variable muscular pressure of the patient. We hypothesized that a PEEP wave maneuver, analyzed with electrical impeda...

Bronchopulmonary dysplasia (BPD), also known as chronic lung disease (CLD), is the most common serious morbidity associated with premature birth, particularly among those infants who have respiratory distress syndrome (RDS) and receive mechanical ventilation after birth. BPD is characterized by lung inflammation and scarring, which are thought to be the effects of excessive (or inadequate) vent...

OBJECTIVES Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better lung-replacement approaches. We investigated the ability of a novel extracorporeal venovenous CO2 removal device to reduce minute ventilation while maintaining normocarbia. DESIGN Prospective animal study. SETTING Government laborato...

This study shows that, over time, diaphragm inactivity with controlled mechanical ventilation (CMV) decreases diaphragm force and produces myofibril damage contributing to the reduced force. We measured in vivo and in vitro diaphragm contractile and morphological properties in 30 sedated rabbits grouped (n = 6) as follows: 1 or 3 days of CMV, 1 or 3 days of 0 cmH(2)O continuous positive airway ...

Inflammation is involved in ventilator-induced diaphragm dysfunction. Toll-like receptor 4 (TLR4) is an important inflammatory factor, but it remains unclear whether TLR4 contributes to ventilator-induced diaphragm dysfunction. This study aimed to investigate the role of TLR4 signaling in ventilator-induced diaphragm dysfunction. Total 30 adult male SD rats were randomly divided into control gr...

UNLABELLED We tested the hypothesis that pressure-support ventilation (PSV) allows a reduction in emergence time and laryngeal mask airway (LMA) removal time after general anesthesia compared to volume-controlled mechanical ventilation (CMV). Because spontaneous breathing (SB) is often used with LMA under general anesthesia, patients were allocated randomly to three groups (CMV, SB and PSV). Th...

COMMENT ON POINT:COUNTERPOINT To the Editor: Optimal may depend on the circumstances and both points have utility (1, 3). We found carbon dioxide manipulation more useful and less dangerous than alveolar hypoxia in acute transitional settings when mechanical controlled ventilation is required in unrepaired ductal or shuntdependant pulmonary blood flow (2). The technical aspects of transitioning...

conclusions it was found that avoiding routine pivotal expertise, increasing consciousness of the nonphysical aspects of patients while providing treatment and presenting exclusive care, utilizing experienced icu nurses, and placing more emphasis on effective communication with patients in order to honor them as human beings can all enhance the holistic quality of care. results the four main th...