HIV infection continues to be a global epidemic, with almost 37 million individuals infected worldwide. Despite considerable effort, there is no vaccine and, once contracted, there is no cure for HIV infection (Escolano et al., 2017). HIV-1 infection can be suppressed for decades by combination antiretroviral therapy, which targets multiple steps in the viral life cycle. However, HIV-1 persists...

HIV infection continues to be a global epidemic, with almost 37 million individuals infected worldwide. Despite considerable effort, there is no vaccine and, once contracted, there is no cure for HIV infection (Escolano et al., 2017). HIV-1 infection can be suppressed for decades by combination antiretroviral therapy, which targets multiple steps in the viral life cycle. However, HIV-1 persists...

The modern era of antiretroviral therapy (ART) for human immunodeficiency virus type 1 (HIV-1) infectionbegan in the mid-1990s with the introduction of 2 new classes of antiretroviral drugs, the protease inhibitors (PIs) and the nonnucleoside reverse-transcriptase inhibitors. Combinations consisting of 1 of these drugs along with 2 nucleoside analogue reverse-transcriptase inhibitors rapidly re...

Queries in template form are gaining in popularity as a means of conveying specific information needs to search engines. We explore the utility of Information Retrieval (IR) techniques in the context of templated queries. Our investigations show that IR techniques known to be well-suited for ad hoc retrieval don’t seamlessly extend to the case of templated queries. We show that what works is a ...

A 560 Gb/s (7x80 Gb/s Nyquist spaced PDM-16QAM) superchannel achieving 6.95 b/s/Hz spectral efficiency (SE) is transmitted over 253.4 km ULLF using only EDFA pre-amplification and full field nonlinear backpropagation, corresponding to a record SE-distance product of 17611.3 b/s/Hz·km. Introduction Achieving a longer span length for a given transmitted capacity is key for unrepeated intercity tr...

This paper examines the question of how a linguistic analysis of a written document can contribute to identifying, tracking and populating the “eventualities” that are presented in the document, either directly or indirectly, and representing degrees of belief concerning them. It is our view that the role of lexical analysis (as exemplified in the research carried out in the FrameNet project) i...

The development of technologies to address machine translation and distillation of multilingual broadcast data depends heavily on the collection of large volumes of material from modern data providers. To address the needs of GALE researchers, the Linguistic Data Consortium (LDC) developed a system for collecting broadcast news and conversation from a variety of Arabic, Chinese and English broa...

Background: The main goal of Joint Genome Institute’s (JGI) Microbial Genome Program is to deliver finished microbial genomes faster, cheaper and better quality. Traditional method of producing multiple subclone libraries and Sanger reads is costly and also time consuming. 454 Life sciences has recently developed a highly scalable, highly parallel high throughput system which does not require t...