نتایج جستجو برای: vivo permeation

تعداد نتایج: 339759  

2015
Teng Guo Yongtai Zhang Jihui Zhao Chunyun Zhu Nianping Feng

BACKGROUND Lipid-based nanosystems have great potential for transdermal drug delivery. In this study, nanostructured lipid carriers (NLCs) for short-acting alkaloids lappacontine (LA) and ranaconitine (RAN) isolated from Aconitum sinomontanum (AAS) at 69.47 and 9.16% (w/w) yields, respectively, were prepared to enhance percutaneous permeation. Optimized NLC formulations were evaluated using uni...

2015
Chuanlong Guo Yan Zhang Zhao Yang Mengshuang Li Fengjie Li Fenghua Cui Ting Liu Weiyun Shi Xianggen Wu

A stable topical ophthalmic cyclosporine A (CsA) formulation with good tolerance and high efficacy is still a desire in pharmaceutics and clinics. This article describes the preparation of CsA containing nanomicelles using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer. Both the polymer itself and the CsA nanomicelles were evaluated for cytotoxicity...

Journal: :European Journal of Pharmaceutics and Biopharmaceutics 2021

In skin penetration studies, HPLC-MS/MS analysis on extracts of heat-separated epidermis and dermis provides an estimate the amount drug penetrated. this study, MALDI-MSI enabled qualitative distribution endogenous molecules molecule, tofacitinib quantitative in epidermis. The delivery to was investigated a Franz diffusion cell using three different formulations (two oil-in-water creams, C1 C2 ...

Journal: :Sci 2021

Animal testing is mandatory in drug and the gold standard for toxicity efficacy evaluations. This situation expected to change future as 3Rs principle, which stands replacement, reduction, refinement of use animals science, reinforced by many countries. On other hand, technologies alternatives animal have increased. The need develop depends on complexity research topic also extent currently use...

Journal: :BMC Dermatology 2003
Catarina Rosado Luis Monteiro Rodrigues

BACKGROUND Transdermal drug delivery has become an important means of drug administration. It presents numerous advantages but it is still limited by the small number of drugs with a suitable profile. The use of solvents that affect the skin barrier function is one of the classic strategies of penetration enhancement. Some of these solvents have well characterised actions on the stratum corneum...

Journal: :European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2013
Tomoyuki Hishida Junji Yoshida Ryo Maeda Genichiro Ishii Keiju Aokage Mitsuyo Nishimura Kanji Nagai

OBJECTIVES Microvascular invasion and microlymphatic permeation are indicators of microscopic tumour invasion into small vessels and have been considered to be powerful prognostic indicators for non-small-cell lung cancer (NSCLC). Several studies have suggested that these should be included in the TNM classification, but, there have been conflicting results regarding the prognostic impact of mi...

Journal: :Drug development and industrial pharmacy 2010
Kalpana S Paudel Dana C Hammell Remigius U Agu Satyanarayana Valiveti Audra L Stinchcomb

CONTEXT The nonpsychoactive cannabinoid, cannabidiol (CBD), has great potential for the treatment of chronic and 'breakthrough' pain that may occur in certain conditions like cancer. To fulfill this goal, suitable noninvasive drug delivery systems need to be developed for CBD. Chronic pain relief can be best achieved through the transdermal route, whereas 'breakthrough' pain can be best allevia...

2016
Rajan Rajabalaya Guok Leen Jestin Chellian Srikumar Chakravarthi Sheba R. David

The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology...

Journal: :Plant physiology 2008
Tracie A Hennen-Bierwagen Fushan Liu Rebekah S Marsh Seungtaek Kim Qinglei Gan Ian J Tetlow Michael J Emes Martha G James Alan M Myers

Mutations affecting specific starch biosynthetic enzymes commonly have pleiotropic effects on other enzymes in the same metabolic pathway. Such genetic evidence indicates functional relationships between components of the starch biosynthetic system, including starch synthases (SSs), starch branching enzymes (BEs), and starch debranching enzymes; however, the molecular explanation for these func...

Journal: :Molecules 2012
Yan Chen Qingqing Wu Zhenghai Zhang Ling Yuan Xuan Liu Lei Zhou

This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumi...

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