AIMS Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through the Texas Alzheimer's Research Consortium cohort. METHODS A total of 399 participants [probable Alzheimer's disease (AD) n = 198, controls n = 201] were available for analysis. The BDNF levels were assayed via multiplex immunoassay. Regression analyse...

Objectives: The study aims to estimate the changes in the serum levels of lipid peroxidation product malondialdehyde (MDA), non-enzymatic antioxidants: vitamin A, E and C and erythrocyte enzymatic antioxidants: superoxide dismutase (SOD) and catalase(CAT) in chronic alcoholic liver disease. Background: Alcohol consumption accounts for about 50% of patients death from end stage liver disease in ...

Recent findings have suggested that aerobic exercise may have a positive effect on brain functioning, in addition to its well-recognized beneficial effects on human physiology. This study confirmed the cognitive effects of aerobic exercise on the human brain. It also examined the relationships between exercise and the serum levels of neurotrophic factors (BDNF, IGI-1, and VEGF). A total of 91 h...

Neurotrophins are a group of nerve growth factors with their protein structure. These proteins play an important role in the growth and metabolism of many cells and maintain nerve, muscle, synaptic potentials, and also helps reduce depression and apoptosis. The aim of this study was to evaluate the effect of 10 weeks low-intensity aerobic training and limited blood flow to the amount of protein...

Alzheimer's disease (AD) is a progressive disease that destroys memory and other important mental activities. Scientists have found that remaining relatively active can lead to better brain activities in those at risk of developing AD. In some Meta-analyses of prospective investigations, a significantly reduced risk of dementia related to midlife exercise have been proven. Most studies have bee...

BACKGROUND Selective serotonin reuptake inhibitors improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of selective serotonin reuptake inhibitors on cognition and serum BDNF levels in patients with vascular dementia are largely unknown. We performed an open-label study to investigate the e...

Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vita...

In a recent issue of Diabetes Care, Thamer et al. (1) addressed the question of whether baseline plasma vitamin C levels influence the outcome of a dietary and exercise intervention in 86 individuals at increased risk for developing type 2 diabetes. Oxidative stress caused by increased formation of reactive oxygen species during physical exercise has previously been proposed to be an important ...

To successfully grow, neurons need to overcome the effects of hostile environments, such as the inhibitory action of myelin. We have evaluated the potential of exercise to overcome the intrinsic limitation of the central nervous system for axonal growth. In line with the demonstrated ability of exercise to increase the regenerative potential of neurons, here we show that exercise reduces the in...