نتایج جستجو برای: vismodegib
تعداد نتایج: 334 فیلتر نتایج به سال:
Outcomes of Vismodegib for Periocular Locally Advanced Basal Cell Carcinoma From an Open-label Trial
1). If these lesions were at the level of the RPE, one would expect themtobevisualizedonFAFimaging.However, theywere completely silent on FAF imaging, suggesting that they may be located deeper than the RPE, at the level of the choriocapillaris.Wedistinguished 3 types of lesions basedon theirmultimodal imaging characteristics in APMPPE. Type 1 lesions seem to be located at the level of the chor...
2-Chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)-benzamide (GDC-0449, vismodegib) is a potent and selective first-in-class small-molecule inhibitor of the Hedgehog signaling pathway and is currently in clinical development. In this study, we investigated the metabolic fate and disposition of GDC-0449 in rats and dogs after a single oral administration of [¹⁴C]GDC-0449. An averag...
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