np-c is a severe, progressive and irreversible neurovisceral disease, which is invariably fatal. np-c is a rare disease, with an estimated minimal incidence of 1/120,000 live births . np-c is caused by mutations in npc1 (~95% of patients) or npc2 genes .defective npc1 and npc2 proteins result in a disruption of lipid metabolism . one of special features of this disorder is heterogeneous manifes...

background: visceral leishmaniasis (vl) has strong links with poverty, substantial medical and veterinary impacts. this review aimed to focus in studies published during 1994-2016 on vl in southeastern iran. methods : the present review is based on expert knowledge and historical studies published during the past 23 yr (1994-2016) on vl in southeastern iran. in addition, related literature foun...

background: visceral leishmaniasis is systematic serous parasitic disease with pub­lic health importance. zoonotic form of visceral leishmaniasis is wide spread in mediterranean basin and south america regions. direct agglutination test (dat) is an accurate, reliable and non-expensive serological test for the diagnosis of visceral leishmaniasis in human and canines but the antigen preparation i...

background: the aim of present study was to determine the seroprevalence of canine visceral leishmaniasis (cvl) among stray and owned dogs in kouhsar district of alborz province, central iran. methods: the study was performed from march 2011 to july 2011 using direct agglutination test (dat). three hundred and thirty seven dogs including 257 stary and 80 owned dogs were selected by random sampl...

background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...

Direct gene transfer has been used to develop molecular genetic interventions for acquired diseases in several animal models. Through the use of intravascular catheters or anatomically localized injection of DNA liposome complexes, specific tissues can be transduced with recombinant genes. Several promising applications of this method for the study of vascular biology have been demonstrated by ...

Nude mice have been used to grow subcutis (s.c.) growing human colorectal tumors, but these tumors rarely metastasize. This is a problem for studies into the biological behavior of metastatic subpopulations of human colorectal cancers. We have followed the evolution of the parental line and of a variant of human colon carcinoma KM12 cells, that were both tumorigenic, following implantation into...

PURPOSE Measurement of autophagy in cancer and correlation with histopathologic grading or clinical outcomes has been limited. Accordingly, we investigated LC3B as an autophagosome marker by analyzing nearly 1,400 tumors from 20 types of cancer, focusing on correlations with clinical outcomes in melanoma and breast cancer. EXPERIMENTAL DESIGN Staining protocols were developed for automated qu...

Primary liver malignancies together with metastatic liver tumors are among the most common tumors in human. The best available treatment option for these diseases is surgical resection. One major parameter which had been considered as contraindication for liver resection owing to technical difficulties in achieving tumor-free margins was the involvement of the hepatocaval confluence. To overcom...

odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. the lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contrapt...