np-c is a severe, progressive and irreversible neurovisceral disease, which is invariably fatal. np-c is a rare disease, with an estimated minimal incidence of 1/120,000 live births . np-c is caused by mutations in npc1 (~95% of patients) or npc2 genes .defective npc1 and npc2 proteins result in a disruption of lipid metabolism . one of special features of this disorder is heterogeneous manifes...

background: visceral leishmaniasis (vl) has strong links with poverty, substantial medical and veterinary impacts. this review aimed to focus in studies published during 1994-2016 on vl in southeastern iran. methods : the present review is based on expert knowledge and historical studies published during the past 23 yr (1994-2016) on vl in southeastern iran. in addition, related literature foun...

background: visceral leishmaniasis is systematic serous parasitic disease with pub­lic health importance. zoonotic form of visceral leishmaniasis is wide spread in mediterranean basin and south america regions. direct agglutination test (dat) is an accurate, reliable and non-expensive serological test for the diagnosis of visceral leishmaniasis in human and canines but the antigen preparation i...

background: the aim of present study was to determine the seroprevalence of canine visceral leishmaniasis (cvl) among stray and owned dogs in kouhsar district of alborz province, central iran. methods: the study was performed from march 2011 to july 2011 using direct agglutination test (dat). three hundred and thirty seven dogs including 257 stary and 80 owned dogs were selected by random sampl...

background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...

Introducción. Desde el 2015, se han reportado casos emergentes de leishmaniosis cutánea localizada (LCL) en Tinum, Yucatán. Sin embargo, no existen registros flebotomíneos peridomicilio. Objetivo. Reportar la presencia antropofílicos peridomicilio un caso LCL municipio Yucatán, México. Materiales y Métodos. Se realizó historia clínica paciente. El diagnóstico identificación especie Leishmania d...

The aim of this study was to determine the respective contribution of abdominal visceral adipose tissue (AT) accumulation and insulin resistance (IR) to the determination of a comprehensive cardiovascular metabolic risk profile in 108 postmenopausal women not receiving hormone therapy. Insulin sensitivity (M/I) was determined by a hyperinsulinemic-euglycemic clamp, and visceral AT area was meas...