Gammaherpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]), Epstein-Barr virus (EBV), and murine gammaherpesvirus 68 (MHV68; also known as gammaherpesvirus 68 [γHV68] or murine herpesvirus 4 [MuHV-4]), establish lifelong latency in the resting memory B cell compartment. However, little is known about how this reservoir of infected mat...

Herpes simplex virus type 1 (HSV-1) has the capacity to establish a life-long latent infection in sensory neurones and also to periodically reactivate from these cells. Since mutant viruses defective for immediate-early (IE) expression retain the capacity for latency establishment it is widely assumed that latency is the consequence of a block in IE gene expression. However, it is not clear whe...

Since the initial development of the "passage A" mouse leukemia virus in 1957, this virus has been propagated in our laboratory by serial passage in newborn C3H(f) mice. At the present time, 10(-2)-10(-3) dilutions in physiological saline solution of this mouse-passaged virus induce lymphatic leukemia in practically all inoculated mice after a latency of 3-5 months. On the other hand, when the ...

By considering the varying latency period of computer virus, we propose a novel model for computer virus propagation in network. Under this model, we give the threshold value determining whether or not the virus finally dies out, and study the local stability of the virusfree and virus equilibrium. It is found that the model may undergo a Hopf bifurcation. Next, we use different methods to prov...

More than 50% of Wistar/Furth (W/Fu) strain rats, which received combined treatment with a fractionated total-body X-irradiation and an injection of a mouse leukemia virus (Gross virus), developed leukemia within 7 months following treatment. The majority of the induced leukemias were thymic lymphomas with a short latency period similar to those observed in susceptible strains of mice and W/Fu ...