Herpes simplex virus type 1 establishes a latent infection in the peripheral nervous system following primary infection. During latent infection, virus genome exhibit limited transcription, with the HSV LATs consistently detected in latency infected ganaglia. Following ocular infection viral latency develops in the trigeminal ganglia. In this study PCR has been used for detection of HSV-1 nuc...

In addition to the respiratory system, severe acute syndrome coronavirus 2 (SARS-CoV-2) strikes other systems, including digestive, circulatory, urogenital, and even central nervous as its receptor angiotensin-converting enzyme (ACE2) is expressed in various organs, such lungs, intestine, heart, esophagus, kidneys, bladder, testis, liver, brain. Different mechanisms, particular, massive virus r...

AIM To evaluate if any association existed between the extent of hepatic necrosis in initial liver biopsies and patient survival. METHODS Thirty-seven patients with fulminant liver failure, whose liver biopsy exhibited substantial necrosis, were identified and included in the study. The histological and clinical data was then analyzed in order to assess the relationship between the extent of ...

Ischemic stress causes neuronal death and functional impairment. Evidence has suggested that cells in the ischemic core first lose viability due to the decline in blood flow and cellular energy metabolism and then die by necrosis. Although inhibition of necrosis could be a potent therapeutic target for brain ischemia, known neurotrophic factors are ineffective for neuronal necrosis. We previous...

Viral vectors have attracted great interest as vehicles for gene therapy. Due to concerns regarding continued viral gene expression in several systems, new approaches have been sought for gene transfer in the nervous system. This article reviews the general concepts and basic biology of defective viral vectors. These are vectors which can package into a viral coat but contain no viral genes, th...

herpes simplex virus type 1 establishes a latent infection in the peripheral nervous system following primary infection. during latent infection, virus genome exhibit limited transcription, with the hsv lats consistently detected in latency infected ganaglia. following ocular infection viral latency develops in the trigeminal ganglia. in this study pcr has been used for detection of hsv-1 nucli...

Background and Objectives: Multiple sclerosis is an inflammatory disease of the central nervous system. This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...

The principal aim of this chapter is to provide an illustrated review of the neuropathologic features of common and recently emerging central nervous system (CNS) viral diseases. An overview of the histopathologic features common to most viral infections of the central nervous system will be provided. This will be followed by a description of the gross and microscopic findings characteristic of...