The curability of the aggressive, large-cell lymphomas was first convincingly reported by Levitt et al in 1972.[1] Patients with “reticulum cell sarcoma” were treated with a regimen that came to be known as COMLA (cyclophosphamide, vincristine [Oncovin], methotrexate, leucovorin, cytarabine [Ara-C]). A more commonly quoted paper was published in 1975 by DeVita et al describing the cure of advan...

L-Asparaginase was added to vincristine and prednisone for induction of first remission in 815 children with acute lymphocytic or acute undifferentiated leukemia. This combination resulted in an overall remission rate of 93%. The addition of L-asparaginse to the standard induction regimen using prednisone and vincristine did not significantly increase the morbidity or mortality rate during the ...

Cytosolic 5′-nucleotidase II (cN-II) and ecto-5′-nucleotidase (CD73) are enzymes involved in the nucleotide metabolism by dephosphorylating nucleoside monophosphates. Both cancer modifying anticancer drug activity, cell biology immune modulation. We have modified lung cells (NCI-H292) to become deficient for either or both using CRISPR/Cas9 technique, studied implication of two cellular respons...

Abstract Quercetin is a plant flavonol from the flavonoid group of polyphenols or can also be formulated as synthetic supplement chemically. Approximately 80 % people in Africa and other developing nations still depend on traditional herbal remedies to treat ailments. has been demonstrated have variety anticancer effects. However, effect quercetin oral cancer cells remains rare. According our s...

The strive of this assessment shows that Vinca rosea, many obviously grown vegetation round us which can be used for medicinal purposes. It has known names like vinca Rosea, Madagascar periwinkle, vibrant eyes, Cape graveyard plant, old maid, crimson rose periwinkle myrtle. Ayurveda is the Indian conventional device medication focuses on scientific capability plant life. Catharanthus roseus one...

BACKGROUND This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody targeting a linear B-cell lactosamine antigen, administered alone and in combination with vincristine in patients with relapsed or refractory B-cell acute lymphoblastic leukemia, and to preliminarily assess tumor targeting and efficacy...

PURPOSE To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment. METHODS Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grad...

Though most follicular lymphoma biomarkers rely on tumor features, the host genetic background may also be relevant for outcome. Here we aimed at verifying the contribution of candidate polymorphisms of FCγ receptor, DNA repair and detoxification genes to prognostic stratification of follicular lymphoma treated with immunochemotherapy. The study was based on 428 patients enrolled in the FOLL05 ...