The development of new approaches to the construction of fluorine-containing target molecules is important for a variety of scientific disciplines, including medicinal chemistry. In this Article, we describe a method for the catalytic enantioselective synthesis of tertiary alkyl fluorides through Negishi reactions of racemic α-halo-α-fluoroketones, which represents the first catalytic asymmetri...

Reactions of tin porphyrins with vicinal diols were investigated. Treatment of (TTP)Sn(CCPh)(2) or (TTP)Sn(NHtolyl)(2) with pinacol and 2,3-diphenylbutane-2,3-diol afforded diolato complexes (TTP)Sn[OC(Me)(2)C(Me)(2)O] (1) and (TTP)Sn[OC(Ph)(Me)C(Ph)(Me)O] (2), respectively. Both complexes underwent C-C cleavage reactions to give (TTP)Sn(II) and ketones. Reaction of (TTP)Sn(CCPh)(2) with 1 equi...

The kinetic roughening behavior of vicinal Si(OO1) surfaces is studied with scanning tunneling microscopy. By analyzing the height-height correlation function of the Si layers that have been grown we found, in the case of islands growth, an algebraic roughening behavior with a roughness exponent of 0.68 * 0.05. In the step flow mode, however, we found non-algebraic roughening behavior.

A highly efficient site-selective desymmetric mono-hydrogenation of 1,4-dienes is reported. This protocol allows rapid access to a wide range chiral allylic alcohols and amides bearing two vicinal centers adjacent the alkene. The utility this method further highlighted by synthesis alkyl side chain zaragozic acid formal total (+)-invictolide.

The development of a new platform to initiate the cascade rearrangement of furans for the formation of functionalized cyclopentenone building blocks is reported. This methodology allows the creation of congested vicinal stereogenic centers with high diastereoselectivity through a 4π-electrocyclization process.

The first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-Reissert compounds and Morita-Baylis-Hillman (MBH) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at C-1 position (up to 94% ee, dr > 20 : 1).

In the title compound, C(18)H(40)N(2)O(2)S(2), a vicinal diamine derivative, the crystal structure is stabilized by two intra-molecular N-H⋯O hydrogen bonds. The distance between the two kernel chiral C atoms is 1.580 (2) Å.

Organosilicon-mediated, regioselective acetylation of vicinal- and 1,3-diols is presented. Methyl trimethoxysilane or dimethyl dimethoxysilane was first used to form cyclic 1,3,2-dioxasilolane or 1,3,2-dioxasilinane intermediates, and subsequent acetate-catalyzed monoacylation was efficiently performed by addition of acetic anhydride or acetyl chloride under mild conditions. The reaction exhibi...

The dynamics of crystal surfaces in the presence of electromigration is analyzed. From a phase field model with a migration force which depends on the local geometry, a step model with additional contributions is derived in the kinetic boundary conditions. These contributions trigger various surface instabilities, such as step meandering, bunching, and pairing on vicinal surfaces. Experiments a...