The plasmalemmal dopamine (DA) transporter (DAT) is a principal site of action for cocaine. This report presents the novel finding that in addition to inhibiting DAT function, cocaine administration rapidly alters vesicular DA transport. Specifically, cocaine treatment abruptly and reversibly increased both the V(max) of DA uptake and the B(max) of vesicular monoamine transporter-2 (VMAT-2) lig...

The vesicular transmitter transporters VGLUT, VGAT, VMAT2 and VAChT, define phenotype and physiological properties of neuronal subtypes. VGLUTs concentrate the excitatory amino acid glutamate, VGAT the inhibitory amino acid GABA, VMAT2 monoamines, and VAChT acetylcholine (ACh) into synaptic vesicle (SV). Following membrane depolarization SV release their content into the synaptic cleft. A stric...

The nervous system adapts to experience by changes in synaptic strength. The mechanisms of synaptic plasticity include changes in the probability of transmitter release and in postsynaptic responsiveness. Experimental and neuropharmacological evidence points toward a third variable in synaptic efficacy: changes in presynaptic transmitter concentration. Several groups, including our own, have re...

Abstract The unexpected intersection of rhyolitic magma and retrieval quenched glass particles at the Iceland Deep Drilling Project-1 geothermal well in 2009 Krafla, Iceland, provide unprecedented opportunities to characterize genesis, storage, behavior subsurface silicic magma. In this study, we analyzed complete time series retrieved after was intersected, terms distribution, chemistry, vesic...

Fatty acid modified Mn(12) derivatives can self-assembly into vesicular structures in organic media. The vesicular assemblies have a sandwich structure with Mn(12) cluster separated by two alkyl chain layers.

The virions of vesicular stomatitis virus contain an enzyme that catalyzes the incorporation of ribonucleotides into RNA. The product of the reaction is mainly RNA complementary in base sequence to that of vesicular stomatitis virus RNA.

glutamate as one of the most important neurotransmitter in the brain has a significant role in control of foodintake. this study examined the central effect of chicago sky blue 6b (csb6 ) as glutamate vesicular uptake inhibitor, on food and water intake in broilers. after icv injection of csb6 cumulative food and water intake were measured in 15,30,60,120 and 180 minutes. csb6 increased food in...

Swine vesicular disease (SVD) is a contagious disease of pigs, caused by an enterovirus and characterised by vesicles on the coronary bands, heels of the feet and occasionally on the lips, tongue, snout and teats. Strains of SVD virus may vary in virulence, and the disease may be subclinical, mild or severe, the latter usually only being seen when pigs are housed on abrasive floors in damp cond...