Labial cavities in vervet monkeys were filled with two luting cements and 2 control materials (negative and positive). Specimens were recovered and examined histo­ logically. There war little difference between the pulpal reactions to the 4 materials. The reactions to the two test materials (luting cements) are, in 28 and 56 day spec­ imens, not more severe than the reactions to the negative co...

African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, naturally infected monkeys. Quantitative competitive reverse transcriptase PCR...

Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for new treatments, the Consortium for Parasitic Drug Development developed novel parenteral diamidin...

Antigenicity of IgG was compared among human, the cynomolgus monkey, the African green monkey and the squirrel monkey by the quantitative precipitation test using purified IgG of and rabbit anti-IgG serum to each species. Clear cross-antigenicity was observed between the cynomolgus monkey and the African green monkey and less clear cross-antigenicity between human and the cynomolgus monkey or t...

Accommodative responses to intramuscular pilocarpine were determined in four surgically aniridic vervet monkeys, before and after eight weeks of daily unilateral topical treatment with echothiophate iodide. The echothiophate-treated eyes maintained maximum myopia during the treatment course. However, after echotiophate treatment was stopped and the refraction had returned to baseline, a subsen...

The results of studies reported previously (1-3) demonstrated heterogeneity in the neutralizing properties of early (7-day) and late (hyperimmune) 7S and 19S antibodies prepared in rabbits against human herpes simplex virus (HSV) and the simian herpesvirus SA8. In the case of the late antibodies, we showed reciprocal cross-neutralization with the 7S antibodies, whereas neutralization by the 19S...

Owing to the lack of oral drugs for human African trypanosomiasis, patients have to be hospitalized for 10 to 30 days to facilitate treatment with parenterally administered medicines. The efficacy of a novel orally administered prodrug, 2,5-bis(4-amidinophenyl)-furan-bis-O-methlylamidoxime (pafuramidine, DB289), was tested in the vervet monkey (Chlorocebus [Cercopithecus] aethiops) model of sle...