We evaluated the effects of zoledronic acid (ZOL) on human gingival fibroblasts (HGFs) and umbilical vein endothelial cells (HUVECs) associated with wound healing in oral soft tissues. HGFs HUVECs were divided into two groups: a culture media control group exposed to ZOL (50 μM). Cell proliferation was measured after 2, 4, 6, 8 days. The migration ability for each experiment using assay. apopto...

background: one of the promising methods in fertility preservation among women with cancer is cryopreservation of ovarian cortex but there are many drawbacks such as apoptosis and considerable reduction of follicular density in the transplanted ovary. one solution to reduce ischemic damage is enhancing angiogenesis after transplantation of ovarian cortex tissue. objective: the aim of this study...

It is well known that the metabolic factors play an important role in the regulation of angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes tissue hypoxia. Hypoxia starts different signals to stimulate angiogenesis and promotes oxygen delivery to tissues. It has been suggested that released adenosine from hypoxic tissues plays a vital role in angiogenesis. ...

Background: Triple-negative breast cancer (TNBC) is treated with highly aggressive non-targeted chemotherapies. Safer and more effective therapeutic approaches than those currently in use are needed. Natural pomegranate peel extract (PPE) has recently been found to inhibit breast cancer progression; however, its mechanisms of action remain unclear. We hypothesized that transcriptional chan...

Wet age-related macular degeneration (wet AMD) is the most common cause of blindness, and chronic intravitreal injection anti-vascular endothelial growth factor (VEGF) proteins has been dominant therapeutic approach. Less a prolonged inter-injection interval are main drivers behind new wet AMD drug innovations. By rationally engineering surface residues model anti-VEGF nanobody, we obtained ser...

Abstract Background About 90% of cancer-related deaths are due to metastasis cancer cells, and angiogenesis is a critical step in this process. sFLT01 novel fusion protein dual-targeting agent that neutralizes both VEGF PlGF proangiogenic activities. GRP78 dual effect tumor growth could be activated under stimulation. The current study was designed investigate the inhibitory impact on VEGF/GRP7...

Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis. This includes developmental angiogenesis as the loss of a single allele is embryonic lethal due to lack of development of endothelial cells. During early development, endothelial cells depend on VEGF for survival and if it is withdrawn, massive apoptosis results. This is not true in adult organisms; withdrawal of...

Physical exercise improves learning and memory abilities by increasing the levels of several growth factors in hippocampus. One factor, vascular endothelial factor (VEGF), is primarily produced muscles not only increases periphery during but can also cross blood-brain barrier. The aim this study to investigate effects regular aerobic chronic on different types muscle fibers relationships betwee...