VEGF-targeting anti-angiogenic drugs have enabled significant advances in cancer therapy. However, acquired resistance to VEGF-targeting drugs occurs, leading to disease progression. How tumors become the resistance remains fully uncertain. One of possible mechanisms for the resistance may be the direct effect of VEGF inhibitors on tumor cells expressing VEGF receptors (VEGF-R). We investigated...

BACKGROUND Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and its expression is increased in non-small cell lung cancer (NSCLC). We aimed to determine the expression pattern of VEGF splice variants in NSCLC and its correlation with the clinicopathological characteristics of tumors. METHODS We used real-time reverse transcription PCR to quantify the mRNA express...

Context: the role of vascular endothelial growth factor (VEGF) and pigment epithelium-derived (PEDF) on renal function diabetics is unclear.
 Objective: This study investigated relationship between VEGF, PEDF urea, creatinine estimated glomerular filtration rate (eGFR) in type 2 diabetics.
 Materials Methods: 100 50 controls were recruited into this case-control study. Analytes determ...

Purpose: To investigate the differential expressions of transforming growth factor-β1 (TGF-β1), hypoxia inductive factor-1 (HIF-1), vascular endothelial factor (VEGF), α-smooth muscle protein (α-SMA) and E-cadherin in renal tissues neonatal rat model hydronephrosis.Methods: The rats (90) were randomly divided into sham group group. further two subgroups: week 1 12 after relief obstruction, with...

Vascular endothelial growth factors (VEGFs) C and D are novel members of the VEGF family that show some selectivity toward lymphatic endothelial cells. Recent studies suggest that VEGF-C may be involved in lymphangiogenesis and spread of cancer cells via lymphatic vessels. However, whether other VEGF family members play a role in lymph node metastasis is largely unknown. The aim of the present ...

PURPOSE The molecular mechanisms underlying lymph node metastasis are poorly understood, despite the well-established clinical importance of lymph node status in many human cancers. Recently, vascular endothelial growth factor (VEGF)-C and VEGF-D have been implicated in the regulation of tumor lymphangiogenesis and enhancement of lymphatic invasion via activation of VEGF receptor-3. The purpose...

Abstract Purpose of Review Malignant pleural effusions (MPEs) are initially treated with thoracocentesis but usually reaccumulate. There is wide variation in the rate recurrence. Those rapid recurrence could benefit from early definitive treatment, whilst those slower recurrences may not. Here, we discuss fluid homeostasis, MPE pathophysiology, and factors associated reaccumulation. Recent Find...

Location of the primary tumor can be prognostic and predictive response to EGFR inhibitors as first-line treatment in mCRC suggesting that cetuximab panitumumab confer little benefit for right side mCRC. HER2 has signaling kinase receptor been successfully targeted breast cancer now showing activity colon cancer. 125 metatstatic unresectable with good PS, 71 males 54 females median age 35.7 yea...