The cyclic peptide phalloidin binds and stabilizes actin filaments. It is widely used in studies of actin filament assembly, including analysis of branch formation by Arp2/3 complex, but its influence on the branching reaction has not been considered. Here we show that rhodamine-phalloidin binds both Arp2/3 complex and the VCA domain of Arp2/3 complex activator, hWASp, with dissociation equilib...

Recently, room-temperature superconductivity has been reported in a nitrogen-doped lutetium hydride at near-ambient pressure [Dasenbrock-Gammon et al., Nature 615, 244 (2023)]. The superconducting properties might arise from Fm3̄m-LuH3−δNε. Here, we systematically study the phase diagram of Lu–N–H 1 GPa using first-principles calculations, and do not find any thermodynamically stable ternary com...

Surface depressions are important topographic characteristics for surface runoff initiation, and the spatial distribution of may further affect timing quantity reaching channels outlets. However, many hydrologic models simulate fill-spill processes depression-dominated areas in a lumped manner release outflows from to or outlets directly. As result, progressive formation contributing area (CA) ...

Sodium-ion batteries (SIBs) and potassium-ion (PIBs) are prospective candidates for large-scale energy storage systems cause of their abundant resources. However, unsatisfactory rate cycling performance carbon-based anodes present a bottleneck the applications SIBs/PIBs due to large sizes sodium/potassium ions. Herein, oxygen-doped vertically aligned carbon aerogels (VCAs) with hierarchically t...

HI data cubes are sources of unique information on interstellar turbulence. Doppler shifts due to supersonic motions contain information on turbulent velocity field which is otherwise difficult to obtain. However, the problem of separation of velocity and density fluctuations within HI data cubes is far from being trivial. Analytical description of the emissivity statistics of channel maps (vel...

INTRODUCTION Complex injuries to the central part of the face are difficult to reconstruct with the current plastic surgery methods. The ultimate one-staged approach to restore anatomy and vital facial functions is to perform a vascularized composite allotransplantation (VCA). METHODS A 54-year-old man suffered from a high-energy ballistic injury, resulting in a large central facial defect. A...

STUDY DESIGN Prospective clinical study. OBJECTIVE To compare the surgical outcomes of vertebral coplanar alignment (VCA) technique against the derotation maneuver with segmental pedicle screw instrumentation in patients with Lenke type 1 idiopathic scoliosis. SUMMARY OF BACKGROUND DATA Nowadays the majority of scoliosis correction begins with rod rotation and translation from the concave s...