In this article, we show how to apply our previously proposed Deletion/Substitution/Addition algorithm in the context of right-censoring for the prediction of survival. Furthermore, we introduce how to incorporate bagging into the algorithm to obtain a cross-validated bagged estimator. The method is used for predicting the survival time of patients with diffuse large B-cell lymphoma based on ge...

Low-frequency variability in geopotential height records of the Northern Hemisphere is a topic of significance in atmospheric science, having profound implications for climate modeling and prediction. A debate has existed in the atmospheric science literature as to whether or not “regimes” or clusters exist in geopotential heights, and if so, how many such clusters. This paper tells the “detect...

The use of rating scales in psychiatry increased in the late 1950s with the introduction of antipsychotics and antidepressants. Initially rating scales were used mainly to evaluate the effectiveness of new medication against placebo. As the need increased for good reliability and validity, further rating scales were developed and these were used not only in clinical trials but also to diagnose ...

This CCR Focuswent to press shortly after the Food and Drug Administration (FDA) approval, on April 28, 2011, of abiraterone in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer. Abiraterone was synthesized in the early 1990s by Mike Jarman’s group at the Institute of Cancer Research, Sutton, Surrey, England. After some delay, clinica...