نتایج جستجو برای: v notch

تعداد نتایج: 321822  

Journal: :TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A 1991

Journal: :Development 2004
Farzad Esni Bidyut Ghosh Andrew V Biankin John W Lin Megan A Albert Xiaobing Yu Raymond J MacDonald Curt I Civin Francisco X Real Michael A Pack Douglas W Ball Steven D Leach

Notch signaling regulates cell fate decisions in a variety of adult and embryonic tissues, and represents a characteristic feature of exocrine pancreatic cancer. In developing mouse pancreas, targeted inactivation of Notch pathway components has defined a role for Notch in regulating early endocrine differentiation, but has been less informative with respect to a possible role for Notch in regu...

Journal: :European Journal of Mechanics A-solids 2022

An extension of the coupled criterion (CC) finite fracture mechanics is established in order to assess dynamic crack initiation. The main change compared classical quasi-static approach consists considering velocity profile during initiation instead assuming an instantaneous proposed enables study under either or loading. It illustrated on several examples including transverse cracking laminate...

Journal: :Transactions of the Japan Society of Mechanical Engineers 1971

Journal: :Journal of immunology 2006
Eva Monsalve Miguel A Pérez Antonio Rubio María José Ruiz-Hidalgo Victoriano Baladrón José J García-Ramírez Juan C Gómez Jorge Laborda María José M Díaz-Guerra

Notch signaling has been extensively implicated in cell-fate determination along the development of the immune system. However, a role for Notch signaling in fully differentiated immune cells has not been clearly defined. We have analyzed the expression of Notch protein family members during macrophage activation. Resting macrophages express Notch-1, -2, and -4, as well as the Notch ligands Jag...

Journal: :Blood 2005
Patrick A Zweidler-McKay Yiping He Lanwei Xu Carlos G Rodriguez Fredrick G Karnell Andrea C Carpenter Jon C Aster David Allman Warren S Pear

Although Notch receptor expression on malignant B cells is widespread, the effect of Notch signaling in these cells is poorly understood. To investigate Notch signaling in B-cell malignancy, we assayed the effect of Notch activation in multiple murine and human B-cell tumors, representing both immature and mature subtypes. Expression of constitutively active, truncated forms of the 4 mammalian ...

2013
Luca Valenti Rosa M. Mendoza Raffaela Rametta Marco Maggioni Chris Kitajewski Carrie J. Shawber Utpal B. Pajvani

Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in human liver would be positively associated with insulin resistance and hepatic steatosis. Here, ...

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