The aim of the study was to assess the expression and clinical significance of C-myc proto-oncogene in the progression of cervical neoplasms. To establish the role of this proto-oncogene in uterine cervix carcinogenesis, we examined 69 tissue samples of: low grade cervical squamous intraepithelial lesions (SIL) (n=16), high grade SIL (n=11), portio vaginalis uteri (PVU) carcinoma in situ (n=11)...

The glutathione content and the activities of several enzymes in its metabolism, glutathione reductase, glutathione peroxidase and γ-glutamyl transpeptidase, were assayed in uteri obtained from estrogen-treated rats and in R3230AC mammary adenocarcinomas obtained from ovariectomized, intact and estrogen-treated hosts. Normal mammary glands, obtained 10–12 days post-partum, were also examined fo...

INTRODUCTION Breast lymphoma accounts for less than 1% of all non-Hodgkin's lymphomas and approximately 0.1% of all breast neoplasms. Most breast lymphomas are classified as diffuse large B-cell lymphomas or as mucosa associated lymphoid tissue lymphomas. Concurrent cases of breast lymphoma and cervical cancer are extremely rare. CASE PRESENTATION We report a case of a 46-year-old woman of un...

cologic origin is sometimes similar to that of disseminated malignant neoplasms (1). This is usually the case in patients with Meigs or pseudo-Meigs syndrome. Meigs syndrome was defined in 1954 as a fibroma or fibromalike tumor associated with hydrothorax and ascites, which resolved on removal of the tumor. Pseudo-Meigs syndrome has an identical clinical constellation but the tumor types which ...

to it, seeing on the one hand the comparative barrenness of past methods of treatment?how many remedies, in fact, have arisen only to be effectually, if not swiftly, dethroned; and, on the other hand, that I am not ready with a great, not to say infallible, specific for the disease. However, I am prepared to offer a few hints which may be of some utility, and which I fancy have not been altoget...

The characteristic distribution of uterine cancer in man with a high incidence in the cervix and a low frequency in the fundus does not obtain in the rabbit. Carcinoma of the uterine fundus is by far the most common of all neoplasms in the rabbit (1) whereas cervical cancer has not been observed in our laboratory nor has its occurrence been reported in the literature. The absence of a squamocol...

BACKGROUND Prior epidemiological evidences suggest that hepatitis B virus (HBV) infection is linked to cancers other than hepatocellular carcinoma. This prospective hospital registry-based case-control study aimed to investigate the sero-epidemiological association between chronic HBV infection and various types of cancer. METHODS 95,034 patients with first-diagnosed non-hepatocellular malign...

To explore the role of DDE, the major and most persistent DDT derivative, in cancer etiology, we examined the association of the 1968 adipose DDE levels of population samples from 22 U.S. states with age-adjusted mortality rates between 1975 and 1994 for multiple myeloma; non-Hodgkin lymphoma (NHL); and cancer of the breast, corpus uteri, liver, and pancreas. Separate analyses were conducted by...