OBJECTIVE To determine the effect of 1,25(OH)(2)D(3) and 25(OH)D(3) vitamin D derivates on the growth of leiomyoma and myometrial cells in vitro. DESIGN In vitro study. SETTING Cell biology research laboratory. PATIENT(S) Six premenopausal women with uterine leiomyomas undergoing hysterectomy. INTERVENTION(S) Samples of leiomyomas and normal myometrial tissue were obtained, and paired c...

Laparoscopic radiofrequency ablation of uterine leiomyomas with a new Federal Drug Administration (FDA)-approved device, a device that delivers radiofrequency energy, is a novel procedure that aims to meet patient and physician demand for effective, minimally invasive leiomyoma treatment. However, as a new procedure, the durability of symptom relief, the safety in widespread use, and ultimately...

Uterine leiomyomata are the most common gynecological benign tumors arise from the smooth muscle cells of the myometrium. The pathogenesis of fibroids is still unclear. Leiomyomas are found in more than half of women over age 35. About 70% of Caucasian women and 80% of African American women have uterine leyomyomata above 50 years of age. Most of patients have small uterine leiomyoma. Giant ute...

BACKGROUND The purpose of this study was to investigate the role of Nucleus accumbens-associated 1 (NAC1) in the development of uterine sarcomas. MATERIALS AND METHODS NAC1 expression and localization in the normal myometrium, benign leiomyoma, and uterine sarcoma were assessed with immunohistochemistry. NAC1-specific siRNA was used to inactivate NAC1 for in vitro biological assays. RESULTS...

The frequency-dependent complex moduli of human uterine tissue have been characterized. Quantification of the modulus is required for developing uterine ultrasound elastography as a viable imaging modality for diagnosing and monitoring causes for abnormal uterine bleeding and enlargement, as well assessing the integrity of uterine and cervical tissue. The complex modulus was measured in samples...

BACKGROUND Uterine leiomyomas are clinically significant tumours that may develop due to an altered differentiation pathway. We have previously identified a dysregulated retinoic acid (RA) pathway that reduced retinoic exposure in human leiomyoma surgical specimens, and have shown that the leiomyoma phenotype was characterized by excessive and disorganized extracellular matrix (ECM). OBJECTIV...

T he uterus is the most common site to develop smooth muscle tumors. Uterine fibroids (leiomyomas) contain benign smooth muscle and fibrous tissues. Twenty percent to 40% of reproductive age women develop uterine fibroids, with a higher incidence in African Americans. Although the decline in hormonal stimulation causes most fibroids to regress at menopause, 20% become symptomatic before then. U...