OBJECTIVE To evaluate the occurrence of residual or recurrent disease after conization for adenocarcinoma in situ (AIS) of the uterine cervix. METHODS Medical records of 99 patients with a histologically diagnosis of AIS of the uterine cervix by conization between 1991 and 2008 were reviewed retrospectively. RESULTS Seventy eight of 99 patients (78.8%) had negative and 18 (18.2%) had positi...

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DN...

If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, inter...

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare and aggressive malignancy with poor prognosis even in its early stage, despite multimodality treatment strategy. Here, we report a case of a woman with clinical polypoid stage IB LCNEC of the cervix, which was detected in her 6-week postpartum checkup. A literature review was also conducted to evaluate current therapeut...

Uterine incarceration is a rare disease of abnormal uterine morphology, the proportion during pregnancy was 1 in 3000 - 10,000. Previously reported patients with have different symptoms. Rarely, asymptomatic cases persist into third trimester pregnancy. In fact, can be and normally carry their fetuses to term because it mainly changes cervix, which does not affect fetal growth utero directly. A...

Haematogenous metastases of breast cancer tumors has previously been demonstrated to frequently occur at the sites of the lung, bones, liver and brain, however presence in the uterine remains a rare occurrence. Metastatic carcinoma of the uterus usually originates from other genital sites, most frequently from the ovaries. The current review presents the first reported case of lobular breast ca...

The aim of this study represents the confirmation of the utility of cytologic investigation in the screening of the preneoplastic and neoplatic lesions of the uterine cervix,comparing the cytologic results with the histolgic diagnosis of the resected specimens.

Female rats are masculinized in utero by male littermates sharing the same uterine horn. Increased anogenital distances in neonatal females and mounting behavior in adult females are related to the presence of males on the caudal side of the females in the uterine horn. Contrary to current beliefs, interamniotic diffusion may not be responsible for the exchange of masculinizing agents among fet...

Introduction and Aim: Dendritic cells (DCs) perform the function of antigen-presenting immune system mammals. After demonstration DCs in human cervix, more focus fell on role distributed various benign cancerous lesions endometrium. In our study, we have studied CD1a positive non-malignant tissues uterus cervix. Materials Methods: A prospective analysis was conducted patients who had undergone ...