Introduction: α-amylase is a major form of amylase found in humans and other mammals. It is the special key enzyme involved in carbohydrates breakdown. Inhibition of this enzyme could be used in treatment of diabetes. In this study, the effect of ten Iranian macrolichens on alpha amylase were tested. Methods: Different concentrations of the extracts (25, 50 and 75 mg/ml) were incubated wi...

Natural products, especially those derived from higher plants, have attracted scientists ancient time because of their potential therapeutic values. Drug development natural sources showed that products or product-derived drugs comprised about 28% all new chemical entities launched to the market. These are originated terrestrial microbes, marine organisms, etc. However, until recently an insign...

give faint yellow crystals, m.p. 235°. It was soluble in NaHCO3 solution and gave brown coloration with FeCl3. Anal. Found: C, 66.76, 66.37; H, 5.44, 5.37. Acetylation of (I)-A mixture of 10g. of (I), 100cc. of Ac2O and 20 drops of conc. H2SO4 was warmed on a water bath for 3hr. and after cooling, the mixture was poured into ice water. Brown precipitates that separated out were treated with MeO...

6. Sands MF, Blume JW, Schwartz SA. Successful treatment of 3 patients with recurrent idiopathic angioedema with omalizumab. J Allergy Clin Immunol. 2007;120:979-81. 7. Metz M, Maurer M. Omalizumab in chronic urticaria. Curr Opin Allergy Clin Immunol. 2012;12:406-11. 8. Rodríguez-Trabado A, Fernández Pereira LM, Romero-Chala S, García-Trujillo JA, Cámara Hijón C. Monitoring omalizumab treatment...

Usnic acid (UA) is a secondary metabolite of lichens that exhibits wide range biological activities. Previously, we found UA derivatives are effective inhibitors tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-topoisomerase (TOP1) stabilized by the TOP1 inhibitor topotecan, neutralizing effect drugs. TDP1 removes damage at 3′ end DNA caused other anticancer agents. Th...