نتایج جستجو برای: urokinase

تعداد نتایج: 6601  

Journal: :Thrombosis research 2008
Yi Liu Chen Wang Yuanhua Yang Xiaoli Hou Jun Wang

The fibrinolytic function of endothelial cells plays an important role in the pathophysiology of pulmonary vascular diseases. In this study, the effects of pro-urokinase, a new thrombolytic drug that is currently being tested for the treatment of pulmonary embolism, on the expression of urokinase-type plasminogen activator (u-PA) and u-PA receptor (u-PAR) were assessed. The role of u-PAR was al...

Journal: :The Biochemical journal 1988
R Fears

1. Possible interactions between fibrin(ogen) and heparin in the control of plasminogen activation were studied in model systems using the thrombolytic agents tissue-type plasminogen activator (t-PA), urokinase and streptokinase.plasminogen activator complex and the substrates Glu- and Lys-plasminogen. 2. Both t-PA and urokinase activities were promoted by heparin and by pentosan polysulphate, ...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
A Yarzábal L Avilán K Hoelzl M de Muñoz J Puig I Kansau

The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to the enzymatic form, plasmin, by t-PA. Affinity chromatography assays revealed a plasminogen-binding protein of 58.9 kDa in water extracts of s...

2009
Herbert B. Schiller Andreas Szekeres Bernd R. Binder Hannes Stockinger Vladimir Leksa

The multifunctional mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is considered a tumor suppressor. We report here that RNA interference with M6P/IGF2R expression in urokinase-type plasminogen activator (uPA)/urokinase-type plasminogen activator receptor (uPAR) expressing human cancer and endothelial cells resulted in increased pericellular plasminogen activation, cell a...

Journal: :Blood 1996
A A Higazi A Mazar J Wang R Reilly J Henkin D Kniss D Cines

Urokinase-type plasminogen activator (uPA) is synthesized as single-chain protein (scuPA) with little intrinsic activity. scuPA is activated when it is converted to two-chain urokinase (tcuPA) by plasmin or when it binds as a single-chain molecule to its cellular receptor (uPAR). Previous data indicate that complexes between scuPA and its receptor have somewhat higher affinity for plasminogen t...

Journal: :The journal of medical investigation : JMI 2000
Y Ikeda T Ikata T Mishiro S Nakano M Ikebe S Yasuoka

To clarify the pathophysiological role of cathepsins in rheumatoid arthritis (RA), we investigated whether cathepsin B or cathepsin L was increased in synovial fluid (SF) of RA joints, and whether the cathepsin isolated from SF of RA patients activated pro-urokinase or not. Thus, we estimated the content of cathepsins in SF of RA patients by measuring their activities by fluorospectrometry, usi...

Journal: :Blood 1998
A A Higazi K Bdeir E Hiss S Arad A Kuo I Barghouti D B Cines

Single-chain urokinase plasminogen activator (scuPA), the unique form secreted by cells, expresses little intrinsic plasminogen activator activity. scuPA can be activated by proteolytic cleavage to form a two-chain enzyme (tcuPA), which is susceptible to inhibition by plasminogen activator inhibitor type I (PAI-1). scuPA is also activated when it binds to its cellular receptor (uPAR), in which ...

Journal: : 2022

Neoangiogenesis is the key process determining myocardial regeneration after infarction. The urokinase-type plasminogen activator receptor (uPAR) known to play an important role in regulation of endothelial cell function and postnatal angiogenesis. However, uPAR its involvement properties vascular progenitor cells remains poorly studied. Aim: evaluate expression on surface resident cardiac (rcV...

Journal: :AJNR. American journal of neuroradiology 2010
W Yoon M S Park K H Cho

BACKGROUND AND PURPOSE Intravenous (IV) thrombolysis often fails to achieve recanalization of occluded cerebral arteries, especially in patients with proximal large arterial occlusions. The goal of this study was to assess the feasibility, safety, and efficacy of low-dose intra-arterial (IA) urokinase and aggressive mechanical clot disruption (AMCD) after failure of IV thrombolysis for acute is...

Journal: :Mechanisms of Development 1997
Susan M Majka Paul G McGuire

During heart development, cells of the endocardial cushions undergo an epithelial-mesenchymal transformation and migrate into the surrounding extracellular matrix. This event is required for the normal formation of valves and chamber septation. Coincident with this phenotypic change is the expression of the serine protease urokinase by the mesenchymal cells. This protease plays an important rol...

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