After uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community. Thus, it has been proposed that uric acid might have caused these disorders. However, uric acid suffered a long period of ignorance in which it was considered a metabolically inert substance. However, rec...

VARIETY of methods is available for tue colorimetric determination of uric acid. In general, these are based on precipitation of proteins, followed by the reduction in an alkaline medium of phosphotungstate by the uric acid ill the protein-free filtrate. Results of colorimetric determinations may at times vary from “true” uric acid values as determined by unease methods. This is because the col...

With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important ...

According to classical concepts, uric acid is presumably filtered at the renal glomeruli andl reabsorbed but not secreted by the renal tubules in man (Berliner et at., 1950). Recent work (Y#{252} and Gutman, 1959) suggests that uric acid may, however, be both secreted and reabsorbed by the tubules. In this species probenecid and salicylates may either increase renal excretion of uric acid, and ...

A practical procedure for evaluating uricosuric agents was demonstrated using clearance experiments with potassium oxonate-treated rats. The fractional excretion value of uric acid showed a reabsorptive net flux of uric acid in the renal tubules of the animal, though the value was obviously higher than those of primates such as men, chimpanzees and cebus monkeys. However, the rats responded wel...

Uric acid was used as a test for liver disease before the advent of enzymology. Three old studies criticised uric acid as a test of liver function. Uric acid, as an end-product of purine metabolism in the liver, deserved re-evaluation as a liver function test. Serum totalbile acids are widely accepted as the most reliable liver function test. This study compared the ability of serum uric acid c...

Maternal, fetal and neonatal complications are correlated with hypertensive disorders during pregnancy.  In this context, the maternal blood uric acid level is reported to be one of the prognostic factors in determining the prenatal outcome.  Based on the existing data, the present descriptive study was performed on two groups of women with severe preeclampsia; the first group (n=53) with a uri...

background: we aimed to estimate the glomerular filtration rate (gfr) in women with polycystic ovary syndrome (pcos) and to determine the relationship between gfr with c-reactive protein (crp) and uric acid. materials and methods: in this cross-sectional study, one-hundred and forty pcos women and 60 healthy subjects were evaluated. the study was carried out at endocrinology outpatient clinic, ...

High blood uric acid level is a risk factor for gout. To reduce the gout complications, patients need to measure their blood uric acid levels and take medication if necessary. Several commercial blood uric acid meters are available in the market. The aim of this study is to investigate the accuracy of two commercial blood uric acid meters, MultiSure and BeneCheck Pluse Meter, on blood uric acid...

Determination of the relative contribution of uric acid level increases to the total measured antioxidative activity could be very useful for testing antioxidative products and their effect on human health. The aim of this report is to present a simple spectrophotometric method that combines the measurement of total antioxidative capacity of a sample by ferric reducing/antioxidative power (FRAP...