In yeast, there are at least two vesicle populations upon ER (endoplasmic reticulum) exit, one containing Gap1p (general aminoacid permease) and a glycosylated alpha-factor, gpalphaF (glycosylated proalpha-factor), and the other containing GPI (glycosylphosphatidylinositol)-anchored proteins, Gas1p (glycophospholipid-anchored surface protein) and Yps1p. We attempted to identify sorting determin...

Pulsatile flow in an in vitro model of the human carotid bifurcation was studied by flow visualization using hydrogen bubble techniques. A glass model was constructed after determining an average geometry from 57 biplanar angiograms of 22 subjects ranging from 34 to 77 years of age. The flow pulse used was a half-sine wave superimposed upon a mean flow. Maximum and minimum values of the instant...

the present paper studies the possibility of propagation of torsional surface waves in an inhomogeneous anisotropic layer lying between two heterogeneous half-spaces (upper and lower half-space). both the half-spaces are assumed to be under compressive initial stress. the study reveals that under the assumed conditions, a torsional surface wave propagates in the medium. the dispersion relation ...

interleukin-1β (il-1β), the prototypical pro-inflammatory cytokine, is produced by macrophages following exposure to bacterial products. its role is to act upon several cell types at the site of infection to stimulate the production of pro-inflammatory molecules that will cause increase in vascular permeability. therefore, il-1β regulates the initiation and development of acute inflammation tha...

The primary objective of the present paper is to explore impact COVID-19 on economy North-Eastern Region (NER) Republic Bulgaria in an effort systematize appropriate mitigation measures minimize effects outbreak. Determining probable crisis NER extremely difficult due pandemic dynamics and constant shifts or changes forecasts related its global development individual countries regions particula...

Strongly interacting electrons in solid-state systems often display tendency towards multiple broken symmetries the ground state. The complex interplay between different order parameters can give rise to a rich phase diagram. Here, we report on identification of intertwined phases with rotational symmetry magic-angle twisted bilayer graphene (TBG). Using transverse resistance measurements, find...

Using molecular dynamics simulations, we study the Jagla model of a liquid which consists of particles interacting via a spherically symmetric two-scale potential with both repulsive and attractive ramps. This potential displays anomalies similar to those found in liquid water, namely expansion upon cooling and an increase of diffusivity upon compression, as well as a liquid-liquid (LL) phase t...