BACKGROUND AND OBJECTIVES Bacteria need iron for growth and most of them can actively acquire Fe ions using especial iron-chelating proteins which named siderophores. We aimed to determine the frequencies of iucA, iroN and irp2 genes in the uropathogenic Escherichia coli (UPEC) isolates. We also analyzed the effects of siderophore genes beside iron supplements on growth rate of the isolates. ...

Urinary tract infection (UTI), a frequent and important disease in humans, is primarily caused by uropathogenic Escherichia coli (UPEC). UPEC forms acute cytoplasmic biofilms within superficial urothelial cells and can persist by establishing membrane-enclosed latent reservoirs to seed recurrent UTI. The host responds with an influx of innate immune cells and shedding of infected epithelial cel...

Adenosine has been identified as a significant inhibitor of inflammation by acting on adenosine A(2A) receptors. In this study, we examined the role of adenosine and A(2A) receptors in the transmigration of human neutrophils across an in vitro model of the transitional bladder urothelium. Human uroepithelial cells (UROtsa) were grown on transwell inserts; uropathogenic Escherichia coli (UPEC) a...

conclusions the trat gene and pai markers were highly prevalent among upec strains isolated from patients in kashan, iran; therefore these determinants could be used as targets for prophylactic interventions. also there was a high level of resistance against the antibiotics commonly used for urinary tract infection treatment. to reach better therapeutic outcomes, treatment regimens have to be m...

extra-intestinal pathogenic escherichia coli (expec) strains are divided into uropathogenic e. coli (upec), strains causing neonatal meningitis and septicaemic e. coli. the most common pathotype of expec is found among patients with urinary tract infection (uti), defined as upec. these bacteria are responsible for >90% of cases of uti and are often found amongst the faecal flora of the same hos...

background:urinary tract infections (utis) are the most common infectious diseases in childhood. the uropathogenic escherichia coli (upec) strains account for as much as 80% of utis. objective:from a clinical perspective, it is important to know which virulence factors and antibiotic resistance properties are present in upec strains in pediatrics. therefore, this study was carried out to invest...

background escherichia coli is one of the most causative pathogen of urinary tract infection. urinary tract infections (utis) are the second most common cause of morbidity and remain a serious health concern among the clinicians. the severity of uti caused by uropathogenic e. coli (upec) is due to the expression of a wide spectrum of virulent factors such as adhesin coding operons. little is kn...

TLR4 plays a central role in resistance to pyelonephritis caused by uropathogenic Escherichia coli (UPEC). It has been suggested that renal tubule epithelial cells expressing TLRs may play a key role in inflammatory disorders and in initiating host defenses. In this study we used an experimental mouse model of ascending urinary tract infection to show that UPEC isolates preferentially adhered t...

background: urinary tract infections are one of the most frequent health problems and uropathogenic escherichia coli is the major pathogen resulting utis. the severity of utis is caused by the expression of a large range of virulence factors.in this study, we evaluated the allelic frequency fimh gene, in upecs isolated from patients with utis. this study also aimed to determine the roles of c64...