Title The variable region of the 3' untranslated region is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in mouse model Author(s) Sakai, Mizuki; Yoshii, Kentaro; Sunden, Yuji; Yokozawa, Kana; Hirano, Minato; Kariwa, Hiroaki Citation Journal of General Virology, 95(4): 823-835 Issue Date 2014-04 Doc URL http://hdl.handle.net/2115/58282 Type article (auth...

The complete genome sequence of a foot-and-and mouth disease virus (FMDV) type A strain (BAN/GA/Sa-197/2013), isolated from Gazipur in Bangladesh, revealed an 84-nucleotide insertion within the 5'-untranslated region (UTR), a lengthened poly(C) tract, and amino acid substitutions at the VP1 region compared to the available genome sequence of the vaccine strain (GenBank accession no. HM854025).

Running title: AMPK-triggered senescence linked to reduced HuR function Abbreviations: ActD, actinomycin D; AICAR, 5-amino-imidazole-4-carboxamide riboside; AMPK, AMP-activated protein kinase; Dex, dexamethasone; ELAV, embryonic lethal abnormal visual; UTR, untranslated region

RNA has been isolated from a human pancreatic somatostatinoma and used to prepare a cDNA library. After prescreening, clones containing somatostatin I sequences were identified by hybridization with an anglerfish somatostatin I-cloned cDNA probe. From the nucleotide sequence of two of these clones, we have deduced an essentially full-length mRNA sequence, including the preprosomatostatin coding...

Foot-and-mouth disease (FMD) is a highly infectious enzootic disease caused by FMD virus. The complete genome sequence of a circulatory FMD virus (FMDV) serotype O isolated from Natore, Bangladesh, is reported here. Genomic analysis revealed antigenic heterogeneity within the VP1 region, a fragment deletion, and insertions at the 5' untranslated region (UTR) and 3A region compared to the genome...

Platelet-derived growth factor (PDGF) is a heterodimeric glycoprotein consisting of A and B chains. A functional promoter had been identified in the 5' flanking region of the human PDGF-A chain gene. We found that the PDGF-A chain promoter region possesses the potential for bidirectional activity. This bidirectional promoter activity is influenced by the 5'-untranslated region (5'-UTR) and seru...

We have recently established that several mRNAs encode the PR264/SC35 splicing factor and that their expression is related to that of c-Myb in human hematopoietic cells. We now report that the various PR264 mRNAs whose expression is transactivated by c-Myb proteins encode an identical PR264/SC35 polypeptide. These mRNAs differ only in their 3' untranslated sequences and exhibit significantly di...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the purpose of this study was to determine the relationship of rs4444903 (egf+61a/g) snp genotype with colorectal cancer and tumor stage in an iranian population. background : epidermal growth factor ( egf ) is one of the important proteins that determine survival of cells. egf binds to its receptor on the cell surface ...

Enhancement of eukaryotic messenger RNA (mRNA) translation initiation by the 3' poly(A) tail is mediated through interaction of poly(A)-binding protein with eukaryotic initiation factor (eIF) 4G, bridging the 5' terminal cap structure. In contrast to cellular mRNA, translation of the uncapped, non-polyadenylated hepatitis C virus (HCV) genome occurs independently of eIF4G and a role for 3'-untr...