PURPOSE OF REVIEW Genetic association studies which survey the entire genome have become a common design for uncovering the genetic basis of common diseases, including lipid-related traits. Such studies have identified several novel loci which influence blood lipids. The present review highlights the statistical challenges associated with such large-scale genetic studies and discusses the avail...

In the present work we study the relationship between population allocation and the combined effects of urban size and energy consumption, for two given areas and through a major part of the twentieth century. Along these lines a general application model is laid down which relates city-growth rates to initial inhabitants and to exosomatic energy increment, the deviations from it showing order ...

Deadline-sensitive workflows require careful coordination of user constraints with resource availability. Current distributed resource access models provide varying degrees of resource control: from limited or none in grid batch systems to explicit in cloud systems. Additionally applications experience variability due to competing user loads, performance variations, failures, etc. These variati...

Through certainty equivalent consumption (CE) measures, we show that dispersion of current earnings, expenditures, and net worth overstate welfare inequality. This is largely due to the unaccounted value future which call human wealth. The latter mitigates permanent‐income inequality, though its influence diminished by growing importance assets in lifetime Average expenditures CE inequality rou...

We propose a new tracking method capable of handling occlusions and non-constant target motion. This is achieved using multiple simple motion models, learned at different temporal scales and combined to capture possibly complex motion patterns. These motion models are learned online in a computationally inexpensive manner. Reliable recovery of tracking after occlusions is achieved by extending ...

We examine the correlation in credit risk using credit default swap (CDS) data. We find that the observable risk factors at the firm, industry, and market levels and the macroeconomic variables cannot fully explain the correlation in CDS spread changes, leaving at least 30 percent of the correlation unaccounted for. This finding suggests that contagion is not only statistically but also economi...

We present density-functional theory calculations of Ru 3d and O 1s surface core-level shifts (SCLSs) at an oxygen-rich Ru(0001) surface, namely for the O(1× 1)/Ru(0001) chemisorption phase and for two surface terminations of fully oxidized RuO2(110). Including final-state effects, the computed SCLSs can be employed for the analysis of experimental X-ray photoelectron spectroscopy (XPS) data en...

In this paper we reconsider recently derived bounds on MeV tau neutrinos, taking into account previously unaccounted for effects. We find that, assuming that the neutrino life-time is longer than O(100 sec), the constraint Neff < 3.6 rules out ντ masses in the range 0.5 (MeV ) < mντ < 35 (MeV ) for Majorana neutrinos and 0.74 (MeV ) < mντ < 35 (MeV ) for Dirac neutrinos. Given that the present ...

Complex simulations are increasingly important in systems analysis and design. In some cases simulations can be exhaustively validated against experiment and taken to be implicitly accurate. However, in domains where only limited validation of the simulations can be performed, implications of simulation studies have historically been qualitative. Validation is notably difficult in cases where e...

Teleoperation systems are subject to different types of disturbances. Such disturbances, when unaccounted for, may cause poor performance and even instability of the teleoperation system. This paper presents a novel nonlinear bilateral control scheme using the concept of disturbance observer based control for nonlinear teleoperation systems. Lumping the effects of dynamic uncertainties and exte...