Eosinophilic esophagitis (EE) is a clinical entity characterized by eosinophilic infi ltration limited to the esophageal epithelium without signifi cant eosinophilic infl ammation of the remainder of the upper gastrointestinal tract mucosa. It can occur in isolation or as part of an atopic spectrum together with asthma, allergic rhinitis and/or atopic dermatitis. EE was fi rst described in the ...

Although over 500 articles have been published in the last 5 years on vertebroplasty, a fundamental question remains—is vertebroplasty a safe and eff ective procedure to reduce pain and disability for patients with vertebral compression fractures? Initial enthusiasm for vertebroplasty was driven by clinician experience and meta-analysis of large observational series showing patient benefi t. Th...

Tung-Min Yu and colleagues report an increased susceptibility to colon, liver, and kidney cancer in patients with autosomal dominant polycystic kidney disease (ADPKD) before receiving renal replacement therapy, when compared with patients without the disease but with a similar (or no) degree of renal impairment. Large studies have shown an excess risk of cancer in patients with chronic kidney d...

Current airway dust ®lter technology emanates from the USA mining industry during the 1930s. It was further developed and improved by the USA military during World War II to prevent workers from inhaling very ®ne radioactive particles in the nuclear industry. These later ®lters we now recognize as high ef®ciency particulate air ®lters (HEPA). The ef®ciency of ®lters varies according to the numb...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 9 2125-2138 www.jem.org/cgi/doi/10.1084/jem.20080099 2125 CD4 + CD25 + Foxp3 + regulatory T cells (T reg cells) are a key checkpoint of T cell activity and are largely responsible for the maintenance of peripheral self-tolerance ( 1 – 4 ). Although their mechanism of action is not yet fully understood, they regulate CD4 and CD8 T...

Recently, another alternative route to the use of purely polymeric structures to attain fl exible Bragg mirrors, and in which enhanced dielectric contrast is achieved, has been successfully demonstrated. [ 22,23 ] Such method takes advantage of multilayers possessing an open porous and interconnected network, which arises as a result of piling up layers of nanoparticles, to infi ltrate a polyme...

A 13-year-old boy was admitted to our dermatology outpatient clinic with red to brown macules on his legs and arms. He had had violaceous to red macules on his legs and feet and similar lesions on his arms 1 year before admission. Apart from these complaints, there were no important features in his history or his family history. On dermatological examination, numerous brownish-red patches, 10 ±...

Polyacrylamide (PAM) use in irrigation for erosion control has increased water in®ltration and reduced soil erosion. This has improved runo€ water quality via lower concentrations of nitrogen, phosphorous, and pesticides, and decreased biological oxygen demand. Since non-toxic high molecular weight anionic PAMs removed clay size sediment particles in ̄owing water, we hypothesized that PAM would...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 12 2915-2927 www.jem.org/cgi/doi/10.1084/jem.20080174 2915 Autoimmune disease is controlled by environments that include gene variants or various cytokines ( 1, 2 ). It can increase susceptibility to autoimmunity by aff ecting the overall reactivity and quality of the cells of the immune system. There is an autoimmune disease spe...

Background: Intraoral adenoid cystic carcinoma is an uncommon pathology with a variable clinical course, it develops as a slow growing swelling characterized by wide local infi ltration. Most patients are in their fourth and sixth decades of life, and females are slightly more affected than males. Case report: An 46-years-old woman was seen at University Hospital of Cuiabá with strong pain in t...