Glucuronidation of morphine in humans is predominantly catalyzed by UDP-glucuronosyltransferase 2B7 (UGT2B7). Since our recent research suggested that cytochrome P450s (P450s) interact with UGT2B7 to affect its function [Takeda S et al. (2005) Mol Pharmacol 67:665–672], P450 inhibitors are expected to modulate UGT2B7catalyzed activity. To address this issue, we investigated the effects of P450 ...

This study examines the influence of interest on development BMT UGT Sidogiri Jakarta Branch by using TPB (Theory Planned Behavior) as theoretical basis and PLS (Partial Lease Square) a tool to measure interest. stands for Baitul Mal wa Tamwil Integrated Joint Venture. These two things are part name which was founded alumni Islamic boarding school. aims examine how can Branch. Seeing that more ...

OBJECTIVE To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis. METHODS Sixty female guinea pigs were randomized into 3 groups: group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltra...

Acylglucuronides formed from carboxylic acids by UDP-glucuronosyltransferases (UGTs) are electrophilic metabolites able to covalently bind proteins. In this study, we demonstrate the reactivity of the acylglucuronide from the nonsteroidal anti-inflammatory drug, ketoprofen, toward human and rat liver UGTs. Ketoprofen acylglucuronide irreversibly inhibited the glucuronidation of 1-naphthol and 2...