نتایج جستجو برای: ucp1 mrna

تعداد نتایج: 154080  

2015
Patricia Pazos Luis Lima Sulay Tovar David González-Touceda Carlos Diéguez María C. García

Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face of hypercaloric diets. Using interleukin18 (Il18) and Il18 receptor 1- knockout (Il18r1-KO) mice, this study aimed to investigate the role of IL18 signaling in BAT and iWAT a...

2017
Sadat A. Aziz Luisa A. Wakeling Satomi Miwa Goiuri Alberdi John E. Hesketh Dianne Ford

SCOPE Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice. METHODS AND RESULTS We observed that application of genistein to 3T3-L1 adipocytes changed the lipid distribution from large droplets to a multilocular distribution, reduced mRNAs indicative of white adi...

Journal: :The Japanese journal of veterinary research 2014
Yasufumi Teramura Akira Terao Yuko Okada Junichi Tomida Yuko Okamatsu-Ogura Kazuhiro Kimura

The effects of three stressors of different categories, namely cold exposure, immobilization, and lipopolysaccharide (LPS) treatment, on sympathetic nerve activity were examined by assessing its biochemical index norepinephrine (NE) turnover in peripheral organs of C57BL/6 mice. NE turnover was assessed by measuring the decrease in the organ NE concentration 3 h after inhibition of catecholamin...

Journal: :The British journal of nutrition 2012
Paula Oliver Antoni Caimari Rubén Díaz-Rúa Andreu Palou

Adiponutrin/PNPLA3 is a protein highly produced in adipose tissue whose expression is under tight nutritional regulation. It possesses lipogenic/lipolytic capacity and, although adiponutrin polymorphisms are related to obesity, its physiological role is not clear. To help clarify its role, we studied the effect of acute cold exposure on adiponutrin mRNA expression in different adipose tissues o...

Journal: :Food frontiers 2023

Adipocytes thermogenesis is an important mechanism for increasing energy expenditure. Here, screening of thermogenic activators (Sirt1 and Ucp1) investigated in C3H10T1/2 cells revealed ethanol extract lotus leaf (LLE) may exert higher activity compared with that the other 11 ingredients. UPLC-MS/MS analysis showed miquelianin was identified as main flavonoid compounds LLE (12.8%) therefore des...

Journal: :Environmental microbiology 2010
John Stavrinides Alexander No Howard Ochman

Aphids are typically exposed to a variety of epiphytic and phytopathogenic bacteria, many of which have entomopathogenic potential. Here we describe the interaction between Pantoea stewartii ssp. stewartii DC283 (DC283), an enteric phytopathogen and causal agent of Stewart's wilt, and the pea aphid, Acyrthosiphon pisum. When ingested by aphids, DC283 establishes and aggregates in the crop and g...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Katrine Almind Monia Manieri William I Sivitz Saverio Cinti C Ronald Kahn

C57BL/6 (B6) mice subjected to a high-fat diet develop metabolic syndrome with obesity, hyperglycemia, and insulin resistance, whereas 129S6/SvEvTac (129) mice are relatively protected from this disorder because of differences in higher basal energy expenditure in 129 mice, leading to lower weight gain. At a molecular level, this difference correlates with a marked higher expression of uncoupli...

Journal: :The Biochemical journal 2009
Aleksandra Swida-Barteczka Andrzej Woyda-Ploszczyca Francis E Sluse Wieslawa Jarmuszkiewicz

We studied non-esterified fatty acid-induced uncoupling of heterologously expressed rat UCP1 (uncoupling protein 1) in yeast mitochondria, as well as UCP1 in rat BAT (brown adipose tissue) mitochondria. The proton-conductance curves and the relationship between the ubiquinone reduction level and membrane potential were determined in non-phosphorylating BAT and yeast mitochondria. The ADP/O meth...

2011
Giuseppe Labruna Fabrizio Pasanisi Giuliana Fortunato Carmela Nardelli Carmine Finelli Eduardo Farinaro Franco Contaldo Lucia Sacchetti

Brown adipose tissue, where Uncoupling Protein 1 (UCP1) activity uncouples mitochondrial respiration, is an important site of facultative energy expenditure. This tissue may normally function to prevent obesity. Our aim was to investigate by sequence analysis the presence of UCP1 gene variations that may be associated with obesity. We studied 100 severe obese adults (BMI > 40 kg/m(2)) and 100 n...

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