Cholesterol gallstone disease is highly prevalent in western countries, particularly in women and some specific ethnic groups. The formation of water-insoluble cholesterol crystals is due to a misbalance between the three major lipids present in the bile: cholesterol, bile salts, and phospholipids. Many proteins implicated in biliary lipid secretion in the liver are regulated by several transcr...

Gallstone ileus is a rare but potentially serious complication of cholelithiasis. It is usually preceded by history of biliary symptoms. It usually occurs as a result of a large gallstone creating and passing through a cholecysto-enteric fistula. Most of the time, the stone will pass the GI tract without any problems, but large enough stones can cause obstruction. The two most common locations ...

Obstruction at the level of the gastric outlet by a gallstone is defined as Bouveret's syndrome. It is an uncommon form of gallstone ileus. A single gallstone of at least 2.5 cm in diameter is the most common underlying cause of Bouveret's syndrome. Diagnosis is based on the clinical manifestations, existence of pneumobilia, visualization of lithiasis and demonstration of duodenal obstruction. ...

BackgroundThe primary aim of this study is to assess characteristics pain in patients with ongoing after total knee arthroplasty (TKA). The secondary identify specific patterns and link these underlying pathologies.MethodsA prospectively collected cohort 97 painful TKA was retrospectively evaluated. All followed a standardized diagnostic algorithm, which led diagnosis that set the indication fo...

In the first paper in this series we presented a typical set of galactic rotation curves associated with the conformal invariant fourth order theory of gravity which has recently been advanced by Mannheim and Kazanas as a candidate alternative to the standard second order Einstein theory. Reasonable agreement with data was obtained for four representative galaxies without the need for any non-l...

Traditional idea generation techniques based on customer input usually collect information on new product needs from a random or typical set of customers. The “lead user process” takes a different approach. It collects information about both needs and solutions from users at the leading edges of the target market, as well as from users in other markets that face similar problems in a more extre...

background: the method of proton induced x-ray emission (pixe) has been widely used as a sensitive technique to trace elemental analysis in both biological and medical fields. the sensitivity of this powerful method is in the order of ppm .the aim of this work is to analyze structural composition of 4 heavy trace elements with z greater than 24 (mn, fe, cu, zn) in two kinds of gallstones and to...