Novel typhoid diagnostics currently under development have the potential to improve clinical care, surveillance, and the disease burden estimates that support vaccine introduction. Blood culture is most often used as the reference method to evaluate the accuracy of new typhoid tests; however, it is recognized to be an imperfect gold standard. If no single gold standard test exists, use of a com...

OBJECTIVES To estimate the costs and benefits of prophylaxis against travel acquired malaria, typhoid fever, and hepatitis A in United Kingdom residents during 1991. DESIGN Retrospective analysis of national epidemiological and economic data. MAIN OUTCOME MEASURES Incidence of travel associated infections in susceptible United Kingdom residents per visit; costs of prophylaxis provision from...

Estimates for the year 2000 suggested that there were approximately 21.5 million infections and 200,000 deaths from typhoid fever globally each year, making the disease one of the most serious infectious disease threats to public health on a global scale. However, these estimates were based on little data, especially from Africa. Global prominence and high-profile outbreaks have created the per...

Typhoid (enteric) fever caused by Salmonella typhi is an important cause of morbidity and mortality (Buckle et al., 2010; Mogasale et al., 2014). The situation is further complicated by increased incidence in some countries of S. Paratyphi A as a cause of enteric fever (Crump et al., 2004). While both diseases share clinical features, paratyphoid fever tends to have a more benign course of illn...

A passive haemagglutination test, using sheep red blood cells sensitised with Salmonella typhi lipopolysaccharide, was compared with the Widal test for the serological diagnosis of typhoid fever in an endemic area. The results obtained on sera from 152 patients with bacteriologically confirmed typhoid and 183 patients who did not have typhoid were analysed in terms of sensitivity, specificity, ...

b a c k g r o u n d  & aim: this study aimed  to estimate  and project  the current  and future disability burden of typhoid fever in iran associated with climate and population to provide best policies for climate change adaptation. methods & materials: years lost due to disabilities (ylds) were measured as burden estimation in this study. the temperature was selected as climate variable. futu...

Background: Typhoid fever, caused by Salmonella typhi, is still a serious problem in many developing countries. It spread eating or drinking food water contaminated with the faeces of an infected person. Risk factors include poor sanitation and hygiene. This study presented mathematical model media campaign component to evaluate possible impact campaigns on typhoid fever awareness. Methods: Six...

Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 mug were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 X 10(8) bacteria per dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody ...

Background & Objectives: Typhoid Ileal perforation is a common problem seen in tropical countries. Over the years advances in the treatment of typhoid fever has decreased the incidence of typhoid ileal perforation. This study is conducted to throw a light on prognostic factors in the surgical outcome of typhoid ileal perforations. Methodology: Fifty consecutive patients clinically diagnosed as ...

BACKGROUND Knowledge of risk factors and their relative importance in different settings is essential to develop effective health education material for the prevention of typhoid. In this study, we examine the effect of household level and individual behavioural risk factors on the risk of typhoid in three Indonesian islands (Sulawesi, Kalimantan and Papua) in the Eastern Indonesian archipelago...