De-ubiquitinating enzymes (DUBs) play critical roles in diverse cellular processes, including intracellular trafficking, protein turnover, inflammatory signaling, and cell transformation. The first DUB to be identified as an oncogene was TRE17/Ubiquitin-specific protease 6 (USP6)/Tre-2. In addition to encoding a USP, TRE17 also contains a TBC (Tre-2/Bub2/Cdc16) domain implicated in GTPase regul...

The contractile vacuole (CV) system is the osmoregulatory organelle required for survival for many free-living cells under hypotonic conditions. We identified a new CV regulator, Disgorgin, a TBC-domain-containing protein, which translocates to the CV membrane at the late stage of CV charging and regulates CV-plasma membrane fusion and discharging. disgorgin(-) cells produce large CVs due to im...

Self-assembled monolayers (SAMs) have recently garnered much interest due to their unique electrical and chemical properties. The limited literature detailing SAM thermal properties has suggested that thermal boundary conductance (TBC) at solid-SAM junctions is not only low, but also insensitive to changes in SAM length as the number of methylene groups (-CH2-) along alkanedithiol chains is var...

Thermal barrier coatings (TBC) are used widely on a range of components that operate at high temperatures. We report measurement of the factor that is required to convert the Raman shift to stress for air plasma sprayed yttria (7 wt %) stabilized tetragonal zirconia (ZrO(2)) (YSZ) thermal barrier coatings. The factor is evaluated for the as-coated condition and also following a heat treatment a...

To achieve high device performance and reliability for the gallium nitride (GaN)-based electron mobility transistors (HEMTs), efficient heat dissipation is important but remains challenging. Enormous efforts have been made to transfer a GaN layer onto diamond substrate with thermal conductivity by bonding. In this work, two GaN-diamond bonded composites are prepared via modified surface activat...

 In this research, a numerical modeling was utilized to calculate the stresses caused during thermal cycling in a functionally graded thermal barrier coating (FG - TBC). The temperature – dependent material response of this protective material was taken into account and the effects of thermal cycle and interface morphology of the ceramic / metallic layer in functionally graded coating system wa...

Thermal barrier coating (TBC) and cooling air systems are among the technologies that have been introduced applied in pursuing extensive development of advanced gas turbine. TBC is used to protect turbine components from higher operating temperature turbine, whereas assist lowering exposure protected surfaces. Generally, a operates three main operational modes, which base load, peak part load. ...

Since solid-state heat transport in a highly porous nanocomposite strongly depends on the thermal boundary conductance (TBC) between constituent nanomaterials, further suppression of TBC is important for improving performance insulators. Here, targeting fabricated by stamping fumed silica nanoparticles, we perform wide variety surface functionalization nanoparticles silane coupling method and i...