It is unarguable that residual tumor volume after primary cytoreductive surgery is the best prognostic factor in clinical course of epithelial ovarian cancer [1]. Nowadays, residual tumor volume does not only predict patients' prognosis but also guides adjuvant treatment strategy including application of targeting drugs. Thus, a growing number of current clinical trials are selecting or stratif...

We used dynamic MRI to evaluate the effects of monoclonal antibodies targeting brain tumor vasculature. Female athymic rats with intracerebral human tumor xenografts were untreated or treated with intetumumab, targeting α(V)-integrins, or bevacizumab, targeting vascular endothelial growth factor (n = 4-6 per group). Prior to treatment and at 1, 3, and 7 days after treatment, we performed standa...

Volume doubling rulers are described for rapid estimation of tumor volume using projection areas of single-plane images such as chest radiographs. The potential utility of the rulers derives in part from the convenient relationships that exist for the interconversion of volume, volume doubling number, and decimal log growth or cell kill. The traditional approach to tumor volume doubling time de...

There is currently no consensus regarding the optimal radiation volume for high-grade glioma (HGG). The brain volume irradiated is associated with the extent of radiation neurotoxicity. When reducing the treatment volume, the risk of geographic tumor miss should be considered. In such cases, the recurrence patterns and, particularly, the rate of marginal tumor recurrence, are important indices ...

Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...

Introduction: In 3DCRT the number of therapeutic fields has dramatic impact on treatment results especially in stomach cancer. Traditionally, for radiotherapy of stomach cancer the therapeutic procedure was using two fields (AP- PA or AP Lateral with wedge) to achieve smooth and homogeneous dose distribution in tumor. But nowadays, adding lateral or oblique fields to aforement...

The tumor volume is a significant prognostic factor in the treatment of malignant tumors. Manual segmentation of brain tumors from MR images is a challenging and time consuming task. In this study a new approach has been discussed to detect the volume of brain tumor using diameter and graph based method to find the volume. Here MRI data set from 200 patients were collected. The graph based on p...

background: cervical cancer has been shown to be highly associated with human papillomavirus (hpv) infection. the viral oncogenes e6 and e7 are constantly expressed by the tumor cells and are therefore potent targets for therapeutic genetic vaccination. in the present study, it was investigated the potential effect of hpv-16 e6, e7 and l1 co-administration to activate specific cytotoxic t lymph...