Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is a crucial effector of immune responses in the brain that participates in the pathogenesis of several acute and chronic neurodegenerative disorders. Accumulating evidence has suggested that TNF-α negatively regulates embryonic and adult neurogenesis. However, the effect of TNF-α on cell fate decision in human neural progenitor cells...

Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...

This study investigated the protective effect of dexmedetomidine (Dex) on lung injury during one-lung ventilation (OLV) in elderly patients undergoing radical esophagectomy with remote ischemic preconditioning (RIPC). Fifty-four esophageal cancer were divided into control, RIPC and RIPC+Dex group. During anesthesia surgery, was performed group, intravenous infusion Dex based conducted At time i...

We report the identification of a new human tumor necrosis factor-alpha (TNF-α) specific peptide selected by competitive panning of a phage library. Competitive elution of phages was obtained using the monoclonal antibody adalimumab, which neutralizes pro-inflammatory processes caused by over-production of TNF-α in vivo, and is used to treat severe symptoms of rheumatoid arthritis. The selected...

background: pre-eclampsia (pe) is a pregnancy associated disorder characterized by hyper-tension and proteinuria. the first 2 stages of pe cause dysfunction in uteroplacental perfusion and oxidative stress while the third stage of pe is due to the release of inflammatory and angiogenic factors, which could lead to maternal endothelial damage and systemic inflammatory response. in this study, we...

background: herpes simplex viruses (hsv) are human pathogens that establish lytic and latent infections. reactivation from latency occurs intermittently, which represents a life-long source for recurrent infection. the role of immune factors in the control of recurrent symptomatic hsv lesions is complex and the exact role of cytokines remains unclear. objective: to assess the levels of tumor ne...

A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies. Lymph node biopsy led to the diagnosis of peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). Immunostaining of the lymph node biopsy specimens for cytokines revealed that the tumor cells were positive for plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vasc...

Cerebrovascular complications and increased risk of encephalopathies are characteristic of preeclampsia and contribute to 40% of preeclampsia/eclampsia-related deaths. Circulating tumor necrosis factor-α (TNF-α) is elevated in preeclamptic women, and infusion of TNF-α into pregnant rats mimics characteristics of preeclampsia. While this suggests that TNF-α has a mechanistic role to promote pree...

Benalu batu (B. medicinalis) is a plant endemic to Central Sulawesi that has been reported possess anticancer, antioxidant, and antiviral activities. The mechanism of action these activities still unclear. This study aimed evaluate the immunostimulatory effect ethanol extract B. medicinalis on an in vivo model by measuring macrophage phagocytotic activity cytokine production tumor necrosis fact...