BACKGROUND The relationship between surgical margin and local recurrence (LR) in osteosarcoma patients with poor responses to chemotherapy is unclear. Moreover, the incidences of LR according to three different resection planes (bone, soft tissue, and perineurovascular) are not commonly known. METHODS We evaluated the incidence of LR in three areas. To assess whether there is a role of surgic...

Submitted (Geliş tarihi): 16.11.2008 Accepted after revision (Düzeltme sonrası kabul tarihi): 07.01.2009 Özet Amaç: Üreterorenoskopiye bağlı olan üreter kopmasında tanısal ve cerrahi yaklaşımların değerlendirilmesi. Gereç ve yöntem: 1999-2007 yılları arasında üreteroskopik cerrahiye bağlı olarak üreter kopması görülen üç hastanın cerrahi onarımı yapıldı. Hastaların ikisinde impakte distal ve mi...

background of the study: colorectal cancer (crc) which is the third most diagnosed cancer throughout the world is steadily rising in the asian countries with the incidence rates mimicking the western counterparts. the pre-neoplastic nature of the transitional mucosa (tm) adjoining crc lacks conclusive evidence so far. pertaining to this, the study of the mucus layer, the functional component of...

background: ewing sarcoma family of tumors (esfts) is the second most common primary tumors of bone in childhood. the decision regarding the optimal modality for achieving local tumor control remains uncertain. the aim of this study was to report the clinical features and outcome as well as reviewing risk factors in patients. materials and methods: this retrospective study included 75 esfts pat...

E xtracapsular dissection with facial nerve dissection (ECD-FND) uses standard surgical landmarks to identify and antegrade dissect the facial nerve trunk at the onset of the procedure. The branches of the facial nerve are dissected up to the anterior extracapsular margin of the tumor; then, the tumor is dissected with a thin layer (1-2 mm) of parenchyma and fascia around it (Figure 1). Extraca...

Preclinical and clinical evidence shows that antiangiogenic agents can decrease tumor vessel permeability and interstitial fluid pressure (IFP) in a process of vessel "normalization." The resulting normalized vasculature has more efficient perfusion, but little is known about how tumor IFP and interstitial fluid velocity (IFV) are affected by changes in transport properties of the vessels and i...

Microvascular invasion is a crucial histopathologic prognostic factor for hepatocellular carcinoma. We reviewed the literature and aimed to draw attention to clinicopathologic and imaging findings that may predict the presence of microvascular invasion in hepatocellular carcinoma. Imaging findings suggesting microvascular invasion are disruption of capsule, irregular tumor margin, peritumoral e...

A 56-year-old man presented with a pigmented lesion on the right preauricular cheek. A biopsy specimen demonstrated lentigo maligna. The lesion was excised in a standard fashion with 0.5-cm margins. Histologic evaluation of the excised specimen showed persistence of the tumor at the surgical margin. A second attempt at excision failed to fully excise the tumor. The patient was referred to our i...

BACKGROUND To analyze patterns of failure in patients with glioblastoma multiforme (GBM) treated with limited-margin radiation therapy and concurrent temozolomide. We hypothesize that patients treated with margins in accordance with Adult Brain Tumor Consortium guidelines (ABTC) will demonstrate patterns of failure consistent with previous series of patients treated with 2-3 cm margins. METHO...

BACKGROUND Managing soft tissue sarcomas (STS) in a developing country with limited financial resources and a poor health referral system is a challenge. Presenting late, these extremity STS are prone to recurrence despite apparently complete resection. This study aimed to explore and compare the impact of clinico-pathological factors on recurrence and survival in Pakistan with the correspondin...