Tumor Angiogenesis It is one of the most widely accepted paradigms in tumor biology that growth of solid tumors is restricted to the ample supply of nutrients. Accordingly, it is assumed that passive diffusion is sufficient for tumor growth only to a size of ≈2 mm in diameter; thus, the tumor connects to capillaries to satisfy its hunger. It was Folkman who first established in 1971 the concept...

The multifunctional growth factor scatter factor/hepatocyte growth factor (SF/HGF) and its receptor tyrosine kinase c-Met have emerged as key determinants of brain tumor growth and angiogenesis. SF/HGF and c-Met are expressed in brain tumors, the expression levels frequently correlating with tumor grade, tumor blood vessel density, and poor prognosis. Overexpression of SF/HGF and/or c-Met in br...

background tendon injuries are common and it takes a long time for an injured tendon to heal. adverse phenomena such as adhesion and rupture are associated with these injuries. finding a method to reduce the time required for healing whichimproves the final outcome, will lead to decreased frequency and intensity of adverse consequences. this study was designed to investigate the effects of basi...

some 190 specimens of sefidrud loach, oxynoemacheilus bergianus , were collected from aras river (northwestern iran) and age, size, and some biological characteristics of the samples were investigated from march to july 2013. the maximum age was 3 + years. the specimens ranged in size from 42 to 64mm for males and 45 to 61mm for females in total length, weighing from 0.62 to 2.03g for males and...

Hepatocyte growth factor/scatter factor (HGF/SF) is a stromally derived modulator of epithelial cell proliferation and morphology. To better assess the potential role of HGF/SF in tumor progression we sought to identify factors and biological conditions which regulate its expression. We show that several adult human primary fibroblast cultures from breast and prostate produce HGF/SF. HGF expres...

Tumor-promoting phorbol esters have been shown previously to either induce or repress the expression of numerous cellular genes, and this property is likely to be important for the in vitro and in vivo biological effects of these compounds. In this report, we demonstrate that phorbol 12-myristate 13-acetate induces the accumulation of basic fibroblast growth factor mRNA and protein in human der...

Tumor-promoting phorbol esters have been shown previously to either induce or repress the expression of numerous cellular genes, and this property is likely to be important for the in vitro and in vivo biological effects of these compounds. In this report, we demonstrate that phorbol 12-myristate 13-acetate induces the accumulation of basic fibroblast growth factor mRNA and protein in human der...

nloaded rrant expression and polymorphism of fibroblast growth factor receptor 4 (FGFR4) has been linked to progression and anticancer drug resistance. We describe here a novel mechanism of tumor progression trix degradation involving epithelial-to-mesenchymal transition in response to membrane-type 1 matrix oproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388...

Background:  New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothes...

background: study in design to incorporate accelerated proliferation correction factors into linearquadratic and multiple-component models. materials and methods: accelerated proliferation rate correction factor has been incorporated into the linearquadratic and the multiple component models by applying accelerated exponential cell growth to explain the tumor cell kinetics and estimates proper ...