Background: Calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase II a key enzyme in apoptosis. In previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. In the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

Calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. It has been reported that this protein has an apoptotic activity in tumor cells. Since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on HT29/219 and SW742 colon carcinoma and adenocarcinoma cell li...

Objective(s) Curative treatment of breast cancer patients using chemotherapy often fails as a result of intrinsic or acquired resistance of the tumor to the drug. ERK is one of the main components of the Ras/Raf/MEK/ERK cascade, which mediates signal from cell surface receptors to transcription factors to regulate different gene expression. In this study, cytotoxicity and the expression of Erk...

Acetylated betulinic acid ( BA ) was converted into mono-substituted benzylamides 2 – 14 . Screening in SRB assays showed them as cytotoxic for a variety of different human tumor cell lines. While parent not within the limits assay (cut-off 30 ​μM), target amides were cytotoxic. Their bioactivity well their cell/non-tumor selectivity depended on substitution pattern aromatic ring. The most acti...

Abstract Atypical teratoid rhabdoid tumor (ATRT) is a rare, aggressive pediatric brain tumor. It characterized by inactivation of SMARCB1 gene. There currently no standard care for treatment. LP-184 an analog acylfulvene. induces cell-cycle arrest and cell apoptosis through alkylation DNA RNA. Previously, was shown to have preclinical efficacy in temozolomide-resistant human glioblastoma lines....

Chaga mushroom (Inonotus obliquus) has been used for a long time as folk medicine treating multiple diseases in several parts of the world without rendering any undesired toxicity. In this study, I. obliquus polysaccharides (IOP) were extracted and assessed to determine their anti-tumorigenic potential human lung cancer cell lines NCI-H23 A549 using cytotoxicity apoptosis assays. MTT assay reve...

objective(s): our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125i]pyk) is promising for the evaluation of the epidermal growth factor receptor (egfr) status and prediction of gefitinib treatment of non-small cell lung cancer. egfr is over-expressed and mutated also in glioblastoma. in the present study,...