نتایج جستجو برای: tumor associated antigen

تعداد نتایج: 1998750  

Journal: :Cancer immunology research 2014
Junko Matsuzaki Takemasa Tsuji Immanuel Luescher Lloyd J Old Protul Shrikant Sacha Gnjatic Kunle Odunsi

Tumor antigen-specific CD4(+) T cells that directly recognize cancer cells are important for orchestrating antitumor immune responses at the local tumor sites. However, the mechanisms of direct MHC class II (MHC-II) presentation of intracellular tumor antigen by cancer cells are poorly understood. We found that two functionally distinct subsets of CD4(+) T cells were expanded after HLA-DPB1*04 ...

Journal: :Neuro-oncology 2022

Abstract The host immune system has developed many mechanisms to defend against and clear virus infections, including PKR, cGAS-STING TLR-MyD88 signaling pathways. Compromised anti-viral in tumor cells allows for infection, replication lysis by oncolytic viruses. However, compromised antiviral mechanisms, together with the microenvironment (TME), limit sensitivity of cells. We generated a novel...

2013
Meenakshi Hegde Amanda Corder Kevin KH Chow Malini Mukherjee Aidin Ashoori Yvonne Kew Yi Jonathan Zhang David S Baskin Fatima A Merchant Vita S Brawley Tiara T Byrd Simone Krebs Meng Fen Wu Hao Liu Helen E Heslop Stephen Gottachalk Eric Yvon Nabil Ahmed

Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed that targeting HER2 in a glioblastoma (GBM) cell line results in the emergence of HER2-null tumor cells that maintain the expression of nontargeted tumor-associated antigens. Combinational targeting of these tumor-associated antigen...

Journal: :Journal of Investigative Dermatology 2000

اسدی, جهانبخش, فخرجو, اشرف, منتظری, علی, مهاجری, عباس, ضرغامی, نصرت اله ,

Introduction & Objective: Breast cancer is the most common disease in women. In the expansion and progression of breast tumors combination of tumor markers including prostate specific antigen (PSA) and telomerase are engaged. The aim of this study was to evaluate relationship between telomerase activity and prostate specific antigen gene expression with steroid hormone receptors in breast can...

Journal: :Engineered regeneration 2021

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent mediated immunity against tumor. The outcome antigen-specific T-cells responses relies interaction between and antigen-presenting cells, which provides signals for generating different phenotypes with roles in tumor removal. However, such often not optimal vivo results low efficacy. To reach full po...

2017
Federico Battisti Chiara Napoletano Hassan Rahimi Koshkaki Francesca Belleudi Ilaria Grazia Zizzari Ilary Ruscito Sara Palchetti Filippo Bellati Pierluigi Benedetti Panici Maria Rosaria Torrisi Giulio Caracciolo Fabio Altieri Marianna Nuti Aurelia Rughetti

Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several piece...

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