نتایج جستجو برای: tumor associated antigen
تعداد نتایج: 1998750 فیلتر نتایج به سال:
Tumor antigen-specific CD4(+) T cells that directly recognize cancer cells are important for orchestrating antitumor immune responses at the local tumor sites. However, the mechanisms of direct MHC class II (MHC-II) presentation of intracellular tumor antigen by cancer cells are poorly understood. We found that two functionally distinct subsets of CD4(+) T cells were expanded after HLA-DPB1*04 ...
Abstract The host immune system has developed many mechanisms to defend against and clear virus infections, including PKR, cGAS-STING TLR-MyD88 signaling pathways. Compromised anti-viral in tumor cells allows for infection, replication lysis by oncolytic viruses. However, compromised antiviral mechanisms, together with the microenvironment (TME), limit sensitivity of cells. We generated a novel...
Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed that targeting HER2 in a glioblastoma (GBM) cell line results in the emergence of HER2-null tumor cells that maintain the expression of nontargeted tumor-associated antigens. Combinational targeting of these tumor-associated antigen...
Introduction & Objective: Breast cancer is the most common disease in women. In the expansion and progression of breast tumors combination of tumor markers including prostate specific antigen (PSA) and telomerase are engaged. The aim of this study was to evaluate relationship between telomerase activity and prostate specific antigen gene expression with steroid hormone receptors in breast can...
Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent mediated immunity against tumor. The outcome antigen-specific T-cells responses relies interaction between and antigen-presenting cells, which provides signals for generating different phenotypes with roles in tumor removal. However, such often not optimal vivo results low efficacy. To reach full po...
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several piece...
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