The development of a safe, effective nonsurgical method of female sterilization that can be performed by paramedical personnel remains a high priority. The method should have a blind delivery system and require only one application. Methyl cyanoacrylate and quinacrine hydrochloride are the two most promising chemical agents. Quinacrine has evolved from instillations of a solution to the develop...

Bulent Berker, MD, Salih Taskin, MD, Elif Aylin Taskin, MD INTRODUCTION Approximately 30 years after its introduction, the use of laparoscopy in gynecology has expanded from diagnosis and tubal sterilization to more sophisticated operations and is even being used for the management of malignancies. Despite rapidly improving technical equipment and surgical skill, complication rates and preventa...

A 33-year-old women with 3 children who has completed child bearing presents to your office for permanent sterilization via a laparoscopic approach. She has recently heard through the internet that removal of the fallopian tubes completely may decrease her ovarian cancer risk more than a tubal ligation with placement of clips or cauterization. She has no family history of gynecologic malignanci...

In many parts of the world, sterilization has become the leading method of fertility control (1). The need to make this procedure s impler , safer , and less expensive-and thereby more acceptable, even in countr ies with limited surgical facilities-is well recognized. Consequently, in the past three decades, various chemicals have been used to accomplish tubal occlusion through transcervical in...

Histopathological and molecular studies suggest that different histological subtypes (histotypes) of ovarian cancer have different aetiologies. Few studies have been large enough to explore reliably the effect of tubal ligation (sterilization), which has been associated with a reduced overall risk of ovarian cancer, on different tumour histotypes. In a prospective study of 1.1 million UK women ...

Extensive research has been undertaken to develop a simple method of non-surgical female sterilization. Zipper and associates identified quinacrine hydrochloride as a drug likely to produce tubal occlusion when placed into the uterus. Zipper's early work with a solution of quinacrine led to the development of quinacrine pellets, a delivery system that was designed to bring the quinacrine into p...