BACKGROUND The success of treatment of chronic hepatitis C (CHC) with pegylated interferon-α (PEG-IFN-α) and ribavirin (RBV) is affected by several host, viral, and treatment factors. This study was designed to describe the association of interleukin (IL) 28B genotypes for rs12979860 with sustained virologic response (SVR) in patients with genotype 1 CHC infection treated with PEG-IFN α-2 and R...

conclusions the diagnosis of the high frequency of solitary ttv and co-infection with hbv, in both liver transplanted patients with cryptogenic and determined cirrhosis, emphasized on the importance of ttv infection in the development of cirrhosis, especially in the cases of cryptogenic ones, prompting for further studies the confirm this agent in the etiology of determined cirrhosis. results t...

Sequence data from four gene regions (nrDNA, petN-psbM, trnD-trnT, trnS-trnG, 3,705 bp) revealed that junipers from the southern mountain ranges of Iran are very diverse. The combined NJ tree (3,705 bp) showed strong support for the distinct nature of J. excelsa, J. polycarpos, J. p. var. turcomanica, and J. p. var. seravschanica. The samples from NW Iran are J. polycarpos and samples from NE I...

Background: Paediatric diarrhoea, the burning issue of nowadays, drastically affects child mortality and morbidity. Apart from virus bacteria, parasites also play an important role in causing diarrhoea at that age group. Giardiasis, most prevalent among parasitic infections, though neglected yet carries significance because its long term health issues. The aim study was to identify intestinal b...

Background: Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram nega...

Natural killer cell responses play a crucial role in virus clearance by the innate immune system. Although the killer immunoglobulin-like receptor (KIR) in combination with its cognate human leukocyte antigen (HLA) ligand, especially KIR2DL3-HLA-C1, is associated with both treatment-induced and spontaneous clearance of hepatitis C virus (HCV) infection in Caucasians, these innate immunity genes...

background torque teno virus (ttv) belongs to the circoviridae family and was separated from japanese patients with elevated levels of serum alanine transferase for the first time. following this, extensive studies have been carried out around the world. objectives the present study was designed to investigate and determine the frequency of ttv genotypes in patients with chronic hepatitis b and...

BACKGROUND/AIMS Single-nucleotide polymorphisms (SNPs) near the interleukin 28B gene (IL28B; interferon [IFN]-λ-3) are associated with outcomes of chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection treated with peginterferon (PEG-IFN) alpha-based antiviral therapy. In this study, we investigated the influence of IL28B polymorphisms on spontaneous clearance of HBV infection in...

BACKGROUND Variation in the IL28B gene is associated with sustained virologic response (SVR) to pegylated interferon plus ribavirin in hepatitis C virus (HCV)-monoinfected patients with genotype 1. Data on other genotypes and on patients coinfected with human immunodeficiency virus (HIV) and HCV are more limited. We aimed to assess the predictive ability of variations in the single-nucleotide p...